16141-26-7

Upstream product

• 492-37-5 hydratropic acid 
• 34009-61-5 diethyl 2-methyl-2-phenylmalonate 
• 1117-96-0 Diazoethan 
• 4370-81-4 3-hydroxy-2-methyl-2-phenylpropanoic acid 

Downstream Products

• 105497-78-7 (-)-2-(diethylamino)ethyl 2-methyl-2-phenyl-3-(tosyloxy)propanoate 
• 105498-87-1 (+)-2-(diethylamino)ethyl 2-methyl-2-phenyl-3-(tosyloxy)propanoate 
• 129808-98-6 2-(diethylamino)ethyl 2-methyl-2-phenyl-3-(tosyloxy)propanoate 
• 129780-03-6 3-Iodo-2-methyl-2-phenyl-propionic acid 2-diethylamino-ethyl ester 
• 129780-02-5 3-Bromo-2-methyl-2-phenyl-propionic acid 2-diethylamino-ethyl ester 
• 129780-01-4 2-(diethylamino)ethyl 2-methyl-2-phenyl-3-chloropropanoate 
• 129780-00-3 2-(diethylamino)ethyl 3-fluoro-2-methyl-2-phenylpropanoate 
• 99545-92-3 (-)-2-(diethylamino)ethyl α-methyltropate 
• 99553-27-2 (+)-2-(diethylamino)ethyl α-methyltropate 
• 129779-99-3 2-(diethylamino)ethyl α-methyltropate 
• 129779-98-2 3-acetoxy-2-methyl-2-phenyl-propionic acid-(2-diethylamino-ethyl ester) 
• 27219-72-3 2-phenyl-2-(chloromethyl)propanoyl chloride 
• 59492-59-0 (-)-(S)-2-methyl-2-phenyl-3-hydroxy-propanoic acid 
• 28968-34-5 (R)-3-hydroxy-2-methyl-2-phenylpropanoic acid 

Relevant academic research and scientific papers

Borylation of Unactivated C(sp3)-H Bonds with Bromide as a Traceless Directing Group

A palladium-catalyzed alkyl C-H borylation with bromide as a traceless directing group is described, providing a convenient approach to access alkyl boronates bearing a β-all-carbon quaternary stereocenter. The protocol features a broad substrate scope, excellent site selectivity, and good functional group tolerance.

New methods for the selective reduction of disubstituted malonates to the corresponding hydroxy-ester derivatives

The reduction of alkylphenylmalonates and dialkylmalonates with LiAl(O- t-Bu)3H proceeds with selective reduction of one of the ester functionalities to provide the hydroxy-ester derivatives in good yields.