16141-90-5

Basic information

• Product Name: 1-(4-FLUOROPHENYL)PIPERAZINE HYDROCHLORIDE
• Synonyms: TIMTEC-BB SBB003383;1-(4-FLUOROPHENYL)PIPERAZINE HYDROCHLORIDE;LABOTEST-BB LT00159934;Nsc149515;Piperazine, 1-(4-fluorophenyl)-, Monohydrochloride
• CAS NO: 16141-90-5
• Molecular Formula: C₁₀H₁₃FN₂*ClH
• Molecular Weight: 216.68
• EINECS: 218-846-6
• Product Categories: pharmacetical
• Mol File: 16141-90-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 182-185 °C(Solv: ethanol (64-17-5))
• Boiling Point: 363.6 °C at 760 mmHg
• Flash Point: 137.8 °C
• Appearance: /
• Density: 1.112 g/cm³
• Vapor Pressure: 1.78E-05mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: 1-(4-FLUOROPHENYL)PIPERAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUOROPHENYL)PIPERAZINE HYDROCHLORIDE(16141-90-5)
• EPA Substance Registry System: 1-(4-FLUOROPHENYL)PIPERAZINE HYDROCHLORIDE(16141-90-5)

Safety Data

• Hazardous Substances Data: 16141-90-5(Hazardous Substances Data)

Usage

General Description

1-(4-Fluorophenyl)piperazine hydrochloride is a chemical compound often used in scientific and medical research. It possesses a fluorine atom at the para-position of the phenyl ring and is often used in the production of various pharmaceuticals because of its inhibition of the reuptake of neurotransmitters like serotonin and norepinephrine. It is known for its applications in neuroscience and psychopharmacology. Despite its scientific significance, this compound needs to be handled with care due to potential health hazards when in direct contact with the skin, eyes, or respiratory system.

InChI:InChI=1/C10H13FN2/c11-9-1-3-10(4-2-9)13-7-5-12-6-8-13/h1-4,12H,5-8H2

Upstream product

• 821-48-7 bis-(2-chloroethyl)amine hydrochloride 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 83082-18-2 6-<2-<4-(4-fluorophenyl)-1-piperazinyl>ethyl>-5,6,7,8-tetrahydro-1,6-naphthyridine difumarate 
• 83081-43-0 6-{3-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-propyl}-5,6,7,8-tetrahydro-[1,6]naphthyridine; compound with (E)-but-2-enedioic acid 
• 1388727-68-1 N-(1-(4-fluorophenyl)piperazin-1-yl)-(13S)-15-acetoxylabd-8-⁽¹⁷⁾-en-19-methyl ester 
• 120301-26-0 2-{4-[4-(4-fluorophenyl)piperazin-1-yl]butyl}-1H-isoindole-1,3(2H)-dione 
• 81514-10-5 1-(3-chloropropyl)-4-(4-fluorophenyl)piperazine 
• 65274-89-7 1-(2-chloroethyl)-4-(4-fluorophenyl)-piperazine 

Relevant articles and documents

Design, synthesis, and systematic evaluation of 4-arylpiperazine- and 4-benzylpiperidine napthyl ethers as inhibitors of monoamine neurotransmitters reuptake

Two series of 4-arylpiperazine- and 4-benzylpiperidine naphthyl ethers were designed based on structure-activity relationship (SAR) and docking model of reported monoamine neurotransmitters reuptake inhibitors. The compounds were synthesized in 3-simple steps and their biological activities were evaluated. Several compounds were proven to be potent inhibitors of serotonin and norepinephrine reuptake. Computer docking was performed to study the interaction of the most potent compound 35 with human serotonin transporter. The results of the analyses suggest that 4-arylpiperazine- and 4-benzylpiperidine naphthyl ethers might be promising antidepressants worthy of further studies.

Exploration of substituted arylpiperazine–tetrazoles as promising dual norepinephrine and dopamine reuptake inhibitors

In the search for potent dual norepinephrine and dopamine reuptake inhibitors, several substituted arylpiperazine–tetrazoles were designed, synthesized and evaluated for their neurotransmitter reuptake inhibitory activities. Various derivatives exhibited selective and strong neurotransmitter reuptake inhibitory activity. In particular, compounds with a three-carbon linker displayed selective and stronger potency than those with two-carbon and four-carbon linkers. Interestingly, six compounds, 9b, 9c, 9d, 9o, 9q and 9u displayed more effective activity than the standard drug, bupropion. The provided SAR data and potent biological activity can offer useful guidelines for designing dual norepinephrine and dopamine reuptake inhibitors as effective therapeutic agents for treatment of several central nervous system diseases.

An efficient scale up process for synthesis of N-arylpiperazines

An efficient protocol for the synthesis of various substituted phenylpiperazines was developed using sulfolane as solvent. The protocol was clean, high yielding and products were obtained in high purities (≥99%). It was also fast and convenient, as the final products were precipitated as hydrochloride salts and could be obtained by filtration. Sulfolane, an aprotic, dipolar, high boiling and recoverable solvent was used as a substitute for common organic solvents.