1614264-91-3

Upstream product

• 61644-18-6 chloromethyl isobutyrate 
• 1614264-83-3 (±)-5-(tert-butoxycarbonyl)-4-(2-chloro-5-nitrophenyl)-6-methyl-3,4-dihydro-2(1H)-pyridone 
• 1614264-72-0 (±)-4-(2-chloro-5-nitrophenyl)-5-[(2-cyanoethyl)oxycarbonyl]-6-methyl-3,4-dihydro-2(1H)-pyridone 
• 1614264-76-4 (±)-5-carboxy-4-(2-chloro-5-nitrophenyl)-6-methyl-3,4-dihydro-2(1H)-pyridone 
• 6361-21-3 2-chloro-5-nitrobenzaldehyde 

Relevant academic research and scientific papers

Chemoenzymatic approach to optically active 1,4-dihydropyridine derivatives

A series of racemic (2-methyl)propanoyloxymethyl 4-aryl-6-chloro-5-methanoyl-2-methyl-1,4-dihydropyridine-3-carboxylates [(±)-5a-h] have been prepared by a four step sequence including a multicomponent Hantzsch process and a Vilsmeier-Haack reaction. The

Chemoenzymatic preparation of optically active 4-aryl-5-carboxy-6-methyl-3, 4-dihydro-2(1H)-pyridone derivatives

A series of racemic 4-aryl-5-(tert-butoxycarbonyl)-6-methyl-3,4-dihydro- 2(1H)-pyridones have been prepared by means of a modified Hantzsch reaction using commercially available starting materials. An easy removal of the tert-butyl group of these pyridones and subsequent reaction with cesium carbonate and chloromethyl 2-methylpropanoate provided us suitable substrates (±)-5 to be used in lipase-catalyzed hydrolysis reactions. Lipase B from Candida antarctica (CAL-B) was the most adequate lipase in the hydrolysis of (±)-5. Despite the low enantioselectivity values obtained (E≤12), several optically active pyridone derivatives were finally isolated with high enantiomeric excesses (ee≥91%) and moderate yields.