161452-15-9Relevant articles and documents
Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment
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, (2008/06/13)
Polyamines having the formula: 1or a salt thereof with a pharmaceutically acceptable acid wherein: R1-R6 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl, optionally having an alkyl chain interrupted by at least one etheric oxygen atom, or hydrogen; N1, N2, N3 and N4 are nitrogen atoms capable of protonation at physiological pH's; a and b may be the same or different and are integers from 1 to 4; A, B and C may be the same or different and are bridging groups which effectively maintain the distance between the nitrogen atoms such that the polyamines: (i) are capable of uptake by a target cell upon administration thereof to a human or non-human animal; and (ii) upon uptake by the target cell, competitively bind via an electrostatic interaction between the positively charged nitrogen atoms to substantially the same biological counter-anions as the intracellular natural polyamines in the target cell; the polyamines, upon binding to the biological counter-anion in the cell, function in a manner biologically different than the intracellular polyamines, the polyamines not occurring in nature; as well as pharmaceutical compositions embodying the polyamines and methods of treating patients requiring anti-neoplastic therapy.
ANALOGS OF BIOLOGICALLY ACTIVE, NATURALLY OCCURRING POLYAMINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF TREATMENT
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, (2008/06/13)
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Antiproliferative Properties of Polyamine Analogues: A Structure-Activity Study
Bergeron, Raymond J.,McManis, James S.,Liu, Charles Z.,Feng, Yang,Weimar, William R.,et al.
, p. 3464 - 3476 (2007/10/02)
A basis set of polyamine analogues was designed and synthesized.These compounds were used to initiate a systematic investigation of the role of chain length, terminal nitrogen alkyl group size, and symmetry of the methylene backbone in the antineoplastic
