151915-07-0Relevant articles and documents
Synthesis and evaluation of unsymmetrical polyamine derivatives as antitumor agents
Wang, Jianhong,Xie, Songqiang,Li, Yanjie,Guo, Yongjun,Ma, Yuanfang,Zhao, Jin,Phanstiel IV, Otto,Wang, Chaojie
, p. 7005 - 7012 (2008/12/22)
A series of unsymmetrically substituted polyamine derivatives were prepared and their cytotoxicities in mouse leukemia L1210, melanoma B16, and HeLa cells were investigated. The in vitro cytotoxicity revealed that these conjugates could recognize the poly
AMINO THIOL COMPOUNDS AND COMPOSITIONS FOR USE IN CONJUNCTION WITH CANCER THERAPY
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Page/Page column 56-57, (2010/02/10)
The invention provides novel polyamine and amino thiol compounds and pharmaceutical compositions for administration in conjunction with cancer chemotherapy or radiation therapy. The compounds are administered locally to provide protection against the adve
The synthesis of N(I),N(II)-diethyl[6-14C]norspermine ([14C]Cl-1006), a new anticancer drug
Hicks, James L.,Huang, Yun
, p. 275 - 284 (2007/10/03)
N(I),N(II)-Diethylnorspermine, CI-1006, a potential new anticancer drug, was synthesized with a carbon-14 located at the central carbon of the molecule. Condensation of N-(2,4,6-trimethylbenzenesulfonyl)-N-ethylpropane-1,3-diamine with diethy[2-14/s
Synthesis and evaluation of unsymmetrically substituted polyamine analogues as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents
Saab,West,Bieszk,Preuss,Mank,Casero Jr.,Woster
, p. 2998 - 3004 (2007/10/02)
Spermidine/spermine-N1-acetyltranferase (SSAT), the rate-limiting step in polyamine catabolism, is critical for the interconversion and modulation of cellular polyamines. Inhibitor-initiated induction of this enzyme also appears to correlate wi