161483-75-6Relevant academic research and scientific papers
Stereoselective synthesis of multiple stereocenters by using a double aldol reaction
Shimoda, Yasushi,Kubo, Tatsunori,Sugiura, Masaharu,Kotani, Shunsuke,Nakajima, Makoto
, p. 3461 - 3464 (2013)
Triple play: The title reaction of an alkyl methyl ketone and two aldehydes using chiral (S)-binapo as a Lewis base catalyst allows access to 1,5-dihydroxy-3-pentanone derivatives with multiple chiral centers in good yields with high diastereo- and enantioselectivities in a single operation (see scheme).
