16152-74-2

Basic information

• Product Name: N-carbobenzoxy-L-prolyl-L-phenylalanyl-N^ω-nitro-L-arginine
• Synonyms: N-carbobenzoxy-L-prolyl-L-phenylalanyl-N^ω-nitro-L-arginine
• CAS NO: 16152-74-2
• Molecular Weight: 597.628
• Mol File: 16152-74-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-carbobenzoxy-L-prolyl-L-phenylalanyl-N^ω-nitro-L-arginine(CAS DataBase Reference)
• NIST Chemistry Reference: N-carbobenzoxy-L-prolyl-L-phenylalanyl-N^ω-nitro-L-arginine(16152-74-2)
• EPA Substance Registry System: N-carbobenzoxy-L-prolyl-L-phenylalanyl-N^ω-nitro-L-arginine(16152-74-2)

Safety Data

• Hazardous Substances Data: 16152-74-2(Hazardous Substances Data)

Upstream product

• 17350-17-3 (S)-2-[(S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxamido]-3-phenylpropanoic acid 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 23631-72-3 N-carbobenzoxy-L-prolyl-L-phenylalanine methyl ester 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 6464-80-8 N-carbobenzoxy-L-prolyl-L-phenylalanyl-N^ω-nitro-L-arginine methyl ester 

Relevant articles and documents

Tri- and tetrapeptide analogues of kinins as potential renal vasodilators

Tri- and tetrapeptide analogues were synthesized and evaluated as renal vasodilators. These peptides were prepared by standard coupling reactions which also provided good yields with hindered α-methyl amino acid derivatives. Preliminary evidence of renal vasodilator activity was determined in anesthetized dogs by measuring the effects on renal blood flow and calculating the accompanying changes in renal vascular resistance. The most potent compounds contained, in their structure, the L-prolyl-DL-α-methylphenylalanyl-L-arginine and L-prolyl-DL-α-methyl-phenyalanylglycyl-L-proline arrays. Substitution on the N-terminal proline with 4-phenylbutyryl and 4-(4-hydroxyphenyl)butyryl side chains produced enhanced renal vasodilator activity and, in certain cases, selectivity for the renal vasculature.