1615230-71-1

Basic information

• Product Name: (2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid
• Synonyms: (2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid
• CAS NO: 1615230-71-1
• Molecular Weight: 349.35
• Mol File: 1615230-71-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid(1615230-71-1)
• EPA Substance Registry System: (2-((6-(p-tolyl)thieno[2,3-d]pyrimidin-4-yl)amino)ethyl)phosphonic acid(1615230-71-1)

Safety Data

• Hazardous Substances Data: 1615230-71-1(Hazardous Substances Data)

Upstream product

• 56844-12-3 6-bromo-4-chlorothieno[2,3-d]pyrimidine 
• 56844-40-7 6-bromothieno[2,3-d]pyrimidin-4(3H)-one 
• 14080-50-3 thieno[2,3-d]pyrimidin-4(3H)one 
• 5720-05-8 4-methylphenylboronic acid 
• 2041-14-7 (2-aminethyl)phosphonic acid 
• 1610772-26-3 4-chloro-6-(p-tolyl)thieno[2,3-d]pyrimidine 

Relevant articles and documents

Multistage screening reveals chameleon ligands of the human farnesyl pyrophosphate synthase: Implications to drug discovery for neurodegenerative diseases

Human farnesyl pyrophosphate synthase (hFPPS) is the gate-keeper of mammalian isoprenoids and the key target of bisphosphonate drugs. Bisphosphonates suffer from poor "drug-like" properties and are mainly effective in treating skeletal diseases. Recent investigations have implicated hFPPS in various nonskeletal diseases, including Alzheimer's disease (AD). Analysis of single nucleotide polymorphisms in the hFPPS gene and mRNA levels in autopsy-confirmed AD subjects was undertaken, and a genetic link between hFPPS and phosphorylated tau (P-Tau) levels in the human brain was identified. Elevated P-Tau levels are strongly implicated in AD progression. The development of nonbisphosphonate inhibitors can provide molecular tools for validating hFPPS as a therapeutic target for tauopathy-associated neurodegeneration. A multistage screening protocol led to the identification of a new monophosphonate chemotype that bind in an allosteric pocket of hFPPS. Optimization of these compounds could lead to human therapeutics that block tau metabolism and arrest the progression of neurodegeneration.