1615240-36-2Relevant academic research and scientific papers
Transition-metal-free synthesis of substituted pyridines via ring expansion of 2-allyl-2H-azirines
Jiang, Yaojia,Park, Cheol-Min,Loh, Teck-Peng
supporting information, p. 3432 - 3435 (2014/07/21)
A new strategy to open the 2-allyl-2H-azirines by 1,8-diazabicyclo[5.4.0] undec-7-ene (DBU) promotion in metal-free conditions affording 1-azatrienes that in situ electrocyclize to the pyridines in good to excellent yields is reported. The reaction displays a broad substrate scope and good tolerance to a variety of substituents including aryl, alkyl, and heterocyclic groups. In addition, one-pot synthesis of pyridines from oximes via in situ formation of 2H-azirines was achieved.
