144501-28-0

Basic information

• Product Name: 2-Phenyl-nicotinic acid ethyl ester
• Synonyms: Ethyl 2-phenylnicotinate;Ethyl 2-phenyl-3-pyridinecarboxylate;2-Phenyl-nicotinic acid ethyl ester;ethyl 2-phenylpyridine-3-carboxylate
• CAS NO: 144501-28-0
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.26
• EINECS: -0
• Mol File: 144501-28-0.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 359.54 °C at 760 mmHg
• Flash Point: 171.244 °C
• Appearance: /
• Density: 1.123 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 2-Phenyl-nicotinic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenyl-nicotinic acid ethyl ester(144501-28-0)
• EPA Substance Registry System: 2-Phenyl-nicotinic acid ethyl ester(144501-28-0)

Safety Data

• Hazardous Substances Data: 144501-28-0(Hazardous Substances Data)

Usage

General Description

2-Phenyl-nicotinic acid ethyl ester is a chemical compound with the molecular formula C16H15NO3. It is an ester of 2-phenyl-nicotinic acid and ethyl alcohol, and is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. 2-Phenyl-nicotinic acid ethyl ester has been reported to exhibit anti-inflammatory and analgesic properties, and is also being studied for its potential use in the treatment of neurodegenerative diseases. Additionally, it has been investigated for its potential as a corrosion inhibitor for steel and as a sunscreen agent due to its UV-absorbing properties. Overall, 2-Phenyl-nicotinic acid ethyl ester is a versatile chemical with a wide range of potential applications in various industries.

InChI:InChI=1/C14H13NO2/c1-2-17-14(16)12-9-6-10-15-13(12)11-7-4-3-5-8-11/h3-10H,2H2,1H3

Upstream product

• 591-50-4 iodobenzene 
• 154366-01-5 2-iodonicotinic acid ethyl ester 
• 53087-78-8 Ethyl 2-bromo-3-pyridinecarboxylate 
• 87606-36-8 2-ethoxy-5-ethoxycarbonyl-6-phenyl-3,4-dihydro-2H-pyran 
• 810665-84-0 ethyl (E)-3-(1-benzoylaziridin-2-yl)acrylate 
• 3885-45-8 ethyl 2,3-dioxo-3-phenylpropanoate 
• 53256-19-2 ethyl (Z)-3-amino-3-phenylacrylate 
• 107-18-6 allyl alcohol 
• 100-47-0 benzonitrile 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 124413-63-4 ethyl 3-amino-3-phenyl-2-propenoate 
• 91540-68-0 2-methylthionicotinic acid ethyl ester 
• 74470-23-8 2-(methylthio)nicotinic acid 
• 1186663-29-5 ethyl 2-(methylsulfonyl)nicotinate 

Downstream Products

• 147936-62-7 3-(chloromethyl)-2-phenylpyridine 
• 54529-38-3 ethyl 2-phenylpiperidine-3-carboxylate 

Relevant articles and documents

Synthesis of Alkyl 2-Phenylnicotinates

Various alkyl 6-ethoxy-2-phenyl-5,6-dihydro-4H-pyran-3-carboxylate 2A are easily to the corresponding nicotinates 3 by reaction with hydroxylamine hydrochloride in refluxing absolute ethanol.

Nickel-Catalyzed Reductive 2-Pyridination of Aryl Iodides with Difluoromethyl 2-Pyridyl Sulfone

A novel nickel-catalyzed reductive cross-coupling between aryl iodides and difluoromethyl 2-pyridyl sulfone (2-PySO2CF2H) enables C(sp2)-C(sp2) bond formation through selective C(sp2)-S bond cleavage, which demonstrates the new reactivity of 2-PySO2CF2H reagent. This method employs readily available nickel catalyst and sulfones as cross-electrophile coupling partners, providing facile access to biaryls under mild reaction conditions without pregeneration of arylmetal reagents.

Scope of regioselective Suzuki reactions in the synthesis of arylpyridines and benzylpyridines and subsequent intramolecular cyclizations to azafluorenes and azafluorenones

The current investigation on regioselective Suzuki reactions of 2,3-dihalopyridines and 2-halo-3-halomethylpyridines yielded the unexplored synthesis of arylpyridines and benzylpyridines bearing synthetic handles for further functionalization. Indeed, the scope of intramolecular cyclizations of arylpyridines and benzylpyridines prepared in this study for the synthesis of azafluorenes and azafluorenones has been investigated.