16156-85-7

Upstream product

• 705-62-4 N,N-dimethyl-N'-phenylthiourea 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 7442-11-7 N,N-diethyl-N'-phenylthiourea 
• 102-08-9 N,N-diphenylthiourea 
• 94126-56-4 3-phenylcarbamoylazo-crotonic acid ethyl ester 
• 52194-41-9 (Z)-ethyl 3-nitrobut-2-enoate 
• 103-72-0 phenyl isothiocyanate 
• 62-53-3 aniline 
• 81852-22-4 ethyl cyano<thio>acetate 
• 146000-77-3 ethyl (E)-3-((E)-carbamoyldiazenyl)but-2-enoate 
• 74376-28-6 ethyl 5-methyl-2-phenylimino-1,3-oxathiole-4-carboxylate 
• 141-97-9 ethyl acetoacetate 

Relevant academic research and scientific papers

Study of reactions between 1,2-diaza-1,3-butadienes and N,N'-diaryl- or N,N'-dialkylthioureas

1,2-Diaza-1,3-butadienes react with N,N'-diarylthioureas to give 2- (arylimino)-2,3-dihydrothiazole derivatives, whereas with N,N'- dialkylthioureas to afford 5,5-disubstituted 3-alkyl-2-(alkylimino)- thiazolidin-4-one derivatives. Under basic conditions,

Catalyst free, regioselective one-pot three-component synthesis of thiazol-2-imine derivatives in ionic liquid

A one-pot three-component approach for the synthesis of thiazol-2-imines has been described by the reaction of amine, phenyl isothiocyanate and β-nitroacrylate in [Hbim]BF4 ionic liquid. The method is applicable for aromatic, benzylic, aliphatic and cyclic amines. Reusable reaction media, regioselectivity, mild reaction condition, catalyst free and high yield of products are the salient features of this protocol.

Reactions of Monoprotic Thioureas with Ethyl α-Chloroacetoacetate, Ethyl Bromomalonate, and Ethyl Bromocyanoacetate

N,N,-Dialkyl-N'-arylthioureas (1) with ethyl α-chloroacetoacetate, furnished dialkylamine hydrochlorides, aryl isothiocyanates, 2-arylimino-1,3-oxathioles (2), 2-arylimino-3-aryl Δ4-thiazolines (3), diarylthioureas (9), and carbonyl sulphide.With ethyl bromomalonate the products were dialkylamine hydrobromides, aryl isothiocyanates, 2-arylimino-3-arylthiazolidin-4-ones (11), and diarylthioureas (9).Ethyl bromocyanoacetate gave an ethyl cyanothio>acetate (13).Compound (13) with triethylamine gave the starting thiourea (1) and diethyl dicyanofumarate.