1615690-95-3Relevant academic research and scientific papers
Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents
Sashidhara, Koneni V.,Dodda, Ranga Prasad,Sonkar, Ravi,Palnati, Gopala Reddy,Bhatia, Gitika
, p. 499 - 509 (2014/06/10)
A series of novel indole-chalcone fibrates were synthesized and their hypolipidemic activity was evaluated in triton WR-1339 induced hyperlipidemic rat model. Preliminary studies indicated that the hybrids 19, 24 and 29 exhibited potent in vitro antioxidant and significant in vivo antidyslipidemic effects. Our results suggest that these new hybrid architectures may serve as promising leads for the development of next generation lipid lowering agents.
