1616248-97-5

Upstream product

• 109-07-9 (RS)-2-methylpiperazine 
• 1616249-14-9 tert-butyl 4-(2-methoxy-4-(4-methylpyridin-3-yl)benzoyl)-2-methylpiperazine-1-carboxylate 
• 1616249-09-2 2-methoxy-4-(4-methylpyridin-3-yl)benzoic acid 
• 120737-78-2 tert-butyl 2-methylpiperazine-1-carboxylate 
• 1616249-06-9 ethyl 2-methoxy-4-(4-methylpyridin-3-yl)benzoate 
• 1616249-05-8 ethyl 2-hydroxy-4-(trifluoromethylsulfonyloxy)benzoate 
• 4143-00-4 ethyl 2,4-dihydroxybenzoate 
• 89-86-1 4-hydroxysalicylic acid 
• 1616249-04-7 ethyl 2-methoxy-4-(((trifluoromethyl)sulfonyl)oxy)benzoate 

Relevant academic research and scientific papers

An iterative in silico and modular synthetic approach to aqueous soluble tercyclic α-helix mimetics

Tercyclic scaffolds, designed to have improved synthetic accessibility and aqueous solubility, were evaluated as structural α-helix mimetics by using an iterative in silico approach. The synthesis of these tercyclic scaffolds was accomplished using a modular synthetic approach by employing functionalised methoxyphenyl units which were readily manipulated to allow the introduction of various nitrogen-based heterocycles. The ability of these scaffolds to mimic the key i, i + 3 and i + 7 residues of a polyalanine α-helix was ratified by in silico studies, X-ray crystallographic and NOESY analysis, and their aqueous solubility was measured by a kinetic turbidimetric method. the Partner Organisations 2014.