1616280-65-9Relevant academic research and scientific papers
Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus
Xu, Jiayi,Lin, Songnian,Myers, Robert W.,Addona, George,Berger, Joel P.,Campbell, Brian,Chen, Hsuan-shen,Chen, Zhesheng,Eiermann, George J.,Elowe, Nadine H.,Farrer, Brian T.,Feng, Wen,Fu, Qinghong,Kats-Kagan, Roman,Kavana, Michael,Malkani, Sunita,McMasters, Daniel R.,Mitra, Kaushik,Pachanski, Michele J.,Tong, Xinchun,Trujillo, Maria E.,Xu, Libo,Zhang, Bei,Zhang, Fengqi,Zhang, Rui,Parmee, Emma R.
, p. 2069 - 2073 (2017/04/10)
Glucokinase (GK, hexokinase IV) is a unique hexokinase that plays a central role in mammalian glucose homeostasis. Glucose phosphorylation by GK in the pancreatic β-cell is the rate-limiting step that controls glucose-stimulated insulin secretion. Similarly, GK-mediated glucose phosphorylation in hepatocytes plays a major role in increasing hepatic glucose uptake and metabolism and possibly lowering hepatic glucose output. Small molecule GK activators (GKAs) have been identified that increase enzyme activity by binding to an allosteric site. GKAs offer a novel approach for the treatment of Type 2 Diabetes Mellitus (T2DM) and as such have garnered much attention. We now report the design, synthesis, and biological evaluation of a novel series of 2,5,6-trisubstituted indole derivatives that act as highly potent GKAs. Among them, Compound 1 was found to possess high in vitro potency, excellent physicochemical properties, and good pharmacokinetic profile in rodents. Oral administration of Compound 1 at doses as low as 0.03?mg/kg led to robust blood glucose lowering efficacy in 3?week high fat diet-fed mice.
NOVEL GLUCOKINASE ACTIVATOR COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT
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Page/Page column 67, (2014/07/08)
Novel pyridine-2-carboxamide derivatives of formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are effective as glucokinase activating agents. Pharmaceutical compositions and methods of treatment are also included.
