1616288-98-2

Upstream product

• 1616291-03-2 8-chloro-7-methoxyisoquinolin-1(2H)-one 
• 86269-98-9 2-chloro-3-methoxybenzoyl chloride 
• 33234-36-5 2-chloro-3-methoxybenzoic acid 
• 100-44-7 benzyl chloride 
• 1616288-95-9 8-chloro-7-hydroxy-3,4-dihydroisoquinolin-1(2H)-one 
• 1616288-94-8 8-chloro-7-methoxy-3,4-dihydroisoquinolin-1(2H)-one 
• 22246-04-4 7-methoxy-3,4-dihydro-2H-isoquinolin-1-one 
• 13623-25-1 6-methoxy-2,3-dihydro-1H-inden-1-one 
• 1303445-99-9 2-(benzyloxy)-3-(chloromethyl)-4,6-dimethylpyridine 
• 1616288-97-1 (8-chloro-1-oxo-3,4-dihydro-2H-isoquinolin-7-yl) N,N-diethylcarbamate 
• 1306439-42-8 [2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methanol 
• 721959-71-3 2-(benzyloxy)-4,6-dimethylpyridine-3-carbaldehyde 
• 53475-53-9 2-(benzyloxy)-4,6-dimethylpyridine-3-carbonitrile 
• 769-28-8 2-hydroxy-4,6-dimethyl-3-carbonitrile 

Downstream Products

• 1616288-99-3 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-8-chloro-7-hydroxy-3,4-dihydroisoquinolin-1(2H)-one 
• 1616289-01-0 2-{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-8-chloro-7-(difluoromethoxy)-3,4-dihydroisoquinolin-1(2H)-one 

Relevant academic research and scientific papers

ARYL FUSED LACTAMS AS EZH2 MODULATORS

This invention relates to compounds of Formula (I) in which R1, R2, R3, R4, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

ARYL AND HETEROARYL FUSED LACTAMS

This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.