188935-04-8Relevant articles and documents
Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCδ and discovery of an ILV analogue of improved isozyme selectivity
Kozikowski, Alan P.,Wang, Shaomeng,Ma, Dawei,Yao, Jiangchao,Ahmad, Shakeel,Glazer, Robert I.,Bogi, Krisztina,Acs, Peter,Modarres, Shayan,Lewin, Nancy E.,Blumberg, Peter M.
, p. 1316 - 1326 (2007/10/03)
Protein kinase C (PKC) is a complex enzyme system comprised of at least 11 isozymes that serves to mediate numerous extracellular signals which generate lipid second messengers. The discovery of isozyme-selective activators and inhibitors (modulators) of