16166-19-1

Upstream product

• 20423-72-7 1,3-dihydro-5-methoxy-1-methyl-3-phenyl-2H-indol-2-one 
• 107-14-2 chloroacetonitrile 
• 557-21-1 zinc(II) cyanide 
• 220580-90-5 4-hydroxy-N-methyl-N-(α-chloro-α-phenylacetyl)aniline 
• 220580-94-9 1-methyl-3-phenyl-5-hydroxyoxindole 
• 2912-62-1 α-chlorophenylacetyl chloride 
• 150-75-4 N-methyl-p-aminophenol 

Downstream Products

• 220581-09-9 1,2,3,3a,8,8a-hexahydro-3a-phenyl-8-methyl-5-methoxypyrrolo<2,3-b>indole 
• 220581-18-0 1,2,3,3a,8,8a-hexahydro-1,8-dimethyl-3a-phenyl-5-methoxypyrrolo<2,3-b>indol-5-ol 
• 220581-13-5 1,2,3,3a,8,8a-hexahydro-1,8-dimethyl-3a-phenyl-5-methoxypyrrolo<2,3-b>indole 

Relevant academic research and scientific papers

Nickel-Catalyzed Intramolecular Arylcyanation for the Synthesis of 3,3-Disubstituted Oxindoles

A nickel-catalyzed arylcyanation reaction for the synthesis of 3,3-disubstituted oxindoles has been developed. This method features a bench-stable precatalyst system and serves as an economical alternative to the existing palladium-catalyzed arylcyanations described to date. A wide scope of oxindole products were accessible in moderate to good yields, and the rich chemistry of the newly installed nitrile functional group was demonstrated in the synthesis of various oxindole derivatives.

Syntheses and biological evaluation of (±)-3a-phenyl congeners of physostigmine and phenserine

(±)-3a-Phenyl congeners of physostigmine and phenserine, synthesized for the first time by a modification of the Julian total synthesis of physostigmine, were evaluated for anticholinesterase action against human acetyl- and butyrylcholinesterase. These a