20423-72-7

Upstream product

• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 
• 20423-71-6 DL-Mandelsaeure-(N-methyl-p-anisidid) 
• 100-52-7 benzaldehyde 
• 25438-37-3 phenyl(trimethylsiloxy)acetonitrile 
• 4358-87-6 (RS)-methyl mandelate 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 39755-95-8 5-methoxyisatine 
• 16077-09-1 5-methoxy-1-methyl-1H-indole-2,3-dione 
• 20423-73-8 3-hydroxy-5-methoxy-1-methyl-3-phenylindolin-2-one 
• 220580-90-5 4-hydroxy-N-methyl-N-(α-chloro-α-phenylacetyl)aniline 
• 2912-62-1 α-chlorophenylacetyl chloride 
• 150-75-4 N-methyl-p-aminophenol 

Downstream Products

• 16166-19-1 2-(5-methoxy-1-methyl-2-oxo-3-phenylindolin-3-yl)acetonitrile 
• 220581-13-5 1,2,3,3a,8,8a-hexahydro-1,8-dimethyl-3a-phenyl-5-methoxypyrrolo<2,3-b>indole 
• 220581-18-0 1,2,3,3a,8,8a-hexahydro-1,8-dimethyl-3a-phenyl-5-methoxypyrrolo<2,3-b>indol-5-ol 
• 220581-09-9 1,2,3,3a,8,8a-hexahydro-3a-phenyl-8-methyl-5-methoxypyrrolo<2,3-b>indole 
• 1312417-53-0 3-allyl-5-methoxy-1-methyl-3-phenylindolin-2-one 

Relevant academic research and scientific papers

Silyl Cyanopalladate-Catalyzed Friedel-Crafts-Type Cyclization Affording 3-Aryloxindole Derivatives

3-Aryloxindole derivatives were synthesized through a Friedel-Crafts-type cyclization. The reaction was catalyzed by a trimethylsilyl tricyanopalladate complex generated in situ from trimethylsilyl cyanide and Pd(OAc) 2. Wide varieties of diethyl phosphates derived from N -arylmandelamides were converted almost quantitatively into oxindoles. When N, N -dibenzylamide was used instead of an anilide substrate, a benzo-fused δ-lactam was obtained. An oxindole product was subjected to substitution reactions to afford 3,3-diaryloxindoles with two different aryl groups.

Palladium-Catalyzed Allylation of Cyclopropyl Acetylenes with Oxindoles to Construct 1,3-Dienes

A novel palladium-catalyzed allylic alkylation of oxindoles with cyclopropyl acetylenes has been developed. Various 1,3-diene oxindole framework bearing a quaternary stereocenter at the C3 position were synthesized straightforwardly in good to excellent yields with high regio-, and stereoselectivities. The reaction exhibited high atom economy and good functional group tolerance.

Palladium-catalyzed allylic alkylation with internal alkynes to construct C-C and C-N bonds in water

A palladium-catalyzed system enabled efficient allylic alkylation with alkynes in water has been developed. This reaction presents an environmentally friendly strategy for constructing lots of allylic compounds with indolinones, ketones, amines as well as electron-rich aromatic compounds as nucleophiles. Moreover, the in situ formed arylallene intermediate adopting alkynes as starting materials omits the need for leaving groups and extra oxidants, showing high atom economy. The versatility of the developed reaction also lends itself to the incorporation of deuteriums by simply replacing H2O with D2O.

Accessing 1,3-Dienes via Palladium-Catalyzed Allylic Alkylation of Pronucleophiles with Skipped Enynes

An unprecedented palladium-catalyzed allylic alkylation of pronucleophiles with unactivated skipped enynes has been developed. This method provides a straightforward access to a wide array of 1,3-dienes without the need to preinstall leaving groups or employ extra oxidants. The reaction exhibited high atom economy, good functional group tolerance, excellent regioselectivities, and scalability. With D2O as cosolvent, deuterium could be incorporated in high efficiency.

Syntheses and biological evaluation of (±)-3a-phenyl congeners of physostigmine and phenserine

(±)-3a-Phenyl congeners of physostigmine and phenserine, synthesized for the first time by a modification of the Julian total synthesis of physostigmine, were evaluated for anticholinesterase action against human acetyl- and butyrylcholinesterase. These a