1616628-00-2Relevant academic research and scientific papers
Synthesis of hyaluronic acid oligosaccharides and exploration of a fluorous-assisted approach
Macchione, Giuseppe,De Paz, José L.,Nieto, Pedro M.
, p. 17 - 25 (2014/07/07)
The synthesis of hyaluronic acid oligomers (tri- and tetrasaccharide) is described. We have followed a pre-glycosylation oxidation strategy. Glucuronic acid units were directly employed in coupling reactions with suitably protected glucosamine derivatives. In order to simplify the purification of synthetic intermediates, a fluorous-assisted strategy has been also explored. Using this approach, a hyaluronic acid trisaccharide was prepared.
