1616685-52-9Relevant academic research and scientific papers
Synergistic catalysis: Highly diastereoselective benzoxazole addition to Morita-Baylis-Hillman carbonates
Ceban, Victor,Putaj, Piotr,Meazza, Marta,Pitak, Mateusz B.,Coles, Simon J.,Vesely, Jan,Rios, Ramon
, p. 7447 - 7450 (2014)
An expedited method has been developed for the diastereoselective synthesis of highly functionalized alkyl-azaarene systems with good yields and high diastereoselectivities (>15:1 dr). The methodology includes a synergistic catalysis event involving organometallic (10 mol% AgOAc) activation of an alkyl azaarene and Lewis base (10 mol% DABCO) activation of a Morita-Baylis-Hillman carbonate. The structure and relative configuration of a representative product were confirmed by X-ray analysis. the Partner Organisations 2014.
