Chemical Communications p. 7447 - 7450 (2014)
Update date:2022-07-29
Topics:
Ceban, Victor
Putaj, Piotr
Meazza, Marta
Pitak, Mateusz B.
Coles, Simon J.
Vesely, Jan
Rios, Ramon
An expedited method has been developed for the diastereoselective synthesis of highly functionalized alkyl-azaarene systems with good yields and high diastereoselectivities (>15:1 dr). The methodology includes a synergistic catalysis event involving organometallic (10 mol% AgOAc) activation of an alkyl azaarene and Lewis base (10 mol% DABCO) activation of a Morita-Baylis-Hillman carbonate. The structure and relative configuration of a representative product were confirmed by X-ray analysis. the Partner Organisations 2014.
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