1616766-72-3

Upstream product

• 1616766-74-5 4-[(1Z,3E)-1-chloro-5-methylhexa-1,3,5-trien-1-yl]benzoic acid 
• 619-44-3 methyl 4-iodobenzoate 
• 1616766-75-6 (R)-4-[2-(4-chlorobenzoyloxy)ethyl]cyclohexa-1,5-diene-1-carboxylic acid 
• 109-00-2 3-HYDROXYPYRIDINE 
• 1616766-80-3 C₃₀H₂₈Cl₂O₆ 
• 1616766-87-0 methyl 4-((triisopropylsilyl)ethynyl)benzoate 
• 225928-10-9 4-(bromoethynyl)benzoic acid methyl ester 
• 1616766-76-7 methyl (Z)-4-(2-bromo-1-chlorovinyl)benzoate 
• 1616766-77-8 (Z)-4-(2-b9romo-1-chlorovinyl)benzoic acid 
• 1616766-88-1 C₁₆H₁₄ClF₃O₅S 
• 78-80-8 2-methylbut-1-en-3-yne 

Relevant academic research and scientific papers

From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins

The synthesis of one of the most potent dual inhibitors of the anti-apoptotic proteins Bcl-xL and Mcl-1 is reported. This analogue of a natural sesquiterpenoid dimer meiogynin A was elaborated by a convergent asymmetric synthesis with 36% yield in ten steps. the Partner Organisations 2014.