1616766-80-3Relevant academic research and scientific papers
From meiogynin A to the synthesis of dual inhibitors of Bcl-xL and Mcl-1 anti-apoptotic proteins
Desrat,Remeur,Gény,Rivière,Colas,Dumontet,Birlirakis,Iorga,Roussi
, p. 8593 - 8596 (2014/07/22)
The synthesis of one of the most potent dual inhibitors of the anti-apoptotic proteins Bcl-xL and Mcl-1 is reported. This analogue of a natural sesquiterpenoid dimer meiogynin A was elaborated by a convergent asymmetric synthesis with 36% yield in ten steps. the Partner Organisations 2014.
