1616876-40-4Relevant academic research and scientific papers
Propargylamine-isothiocyanate reaction: Efficient conjugation chemistry in aqueous media
Viart,Larsen,Tassone,Andresen,Clausen
, p. 7800 - 7802 (2014/07/08)
A coupling reaction between secondary propargyl amines and isothiocyanates in aqueous media is described. The reaction is high-yielding and affords cyclized products within 2-24 h. A functionalized ether lipid was synthesized in 8 steps, formulated as liposomes with POPC and conjugated to FITC under mild conditions using this method. This journal is the Partner Organisations 2014.
