1617-72-7Relevant articles and documents
Synthesis and characterization of some new 1,2,3-thiadiazole and 1,2,3-selenadiazole triterpene derivatives from allobetulone and 2-oxoallobetulin
Dinh Ngoc, Thuc
, p. 1665 - 1671 (2020/04/30)
The synthesis of new 1,2,3-thiadiazole and 1,2,3-selenadiazole derivatives from triterpenoid ketones has been investigated via the corresponding semicarbazones. The intermediates 5, 8 have also been isolated, separated and their structures identified. The Hurd–Mori reaction and Lalezari method have been applied to synthesize a series of new substances 6 and 7. The regioselectivity of the functionalization mostly was centered at the C-3 position for the products 9 and 10. The structures of these compounds were confirmed by 2D-NMR spectroscopy.
Betulinol derivative and hydrophilic modification product thereof, nano solution and preparation method of nano solution
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Paragraph 0076; 0090-0095, (2020/11/09)
The invention relates to a betulin derivative and a hydrophilic modification product thereof, and a nano solution and a preparation method thereof, wherein the betulin derivative is a product obtainedby an esterification reaction of the 3-hydroxyl of betulin or the derivative thereof and the carboxyl in a benzoic acid derivative, the hydrophilic modification product is dispersed in water, a metalhydroxide salt is added, stirring is performed for 30-300 minutes at 25-90 DEG C, naturally cooling is performed to room temperature so as to make the compound form a carboxyl metal salt, a surfactant accounting for 0.1-10% of the volume of the reaction system is added, and ultrasonic treatment is performed for 0-60 min to obtain the nano colloid aqueous solution of the hydrophilic modification product of betulin and derivatives thereof, wherein the nano colloid aqueous solution is good in dispersity, ideal in particle size range and easy to absorb by organisms.
The synthesis of α,β-unsaturated 18αH,19βH-ursane methyl ketones
Nazarov, Mikhail A.,Tolmacheva, Irina A.,Grishko, Victoria V.
, p. 267 - 276 (2020/02/13)
An efficient and facile synthetic technique of a new α,β-unsaturated ketones of 18αH,19βH-ursane type from betulin and a possibility of their further heterocyclization to C20 pyrazoline derivative are reported. The synthetic scheme involves aldol condensa
