1617-94-3

Upstream product

• 6954-50-3 1-isonicotinoyl-4-phenylthiosemicarbazide 
• 15152-50-8 1-isonicotinoyl-4-phenyl-3-semicarbazide 
• 54-85-3 isoniazid 
• 103-72-0 phenyl isothiocyanate 
• 55-22-1 pyridine-4-carboxylic acid 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 14389-12-9 5-(4-pyridyl)tetrazole 
• 103-71-9 phenyl isocyanate 
• 4426-68-0 phenyl isoselenocyanate 
• 5285-87-0 phenyl thiocyanate 
• 18440-58-9 1-(N-phenylhydrazono)-1-chloropropanone 

Relevant academic research and scientific papers

Novel 1,3,4-oxadiazole motifs bearing a quinoline nucleus: Synthesis, characterization and biological evaluation of their antimicrobial, antitubercular, antimalarial and cytotoxic activities

A series of quinoline based 1,3,4-oxadiazole derivatives (8a-l) were synthesized by a chloro-amine coupling reaction approach with different catalysts and solvents. Substituted 1,3,4-oxadiazole intermediates 7a-c were obtained from 2-substituted-N-phenylh

Efficient and mild synthesis of substituted 2-amino-1,3,4-oxadiazoles mediated by (tosylimino)phenyl-γ3-iodane

A simple and convenient one-pot protocol for the synthesis of substituted 2-amino-1,3,4-oxadiazoles mediated by (tosylimino)phenyl-γ3- iodane has been described. Acylthiosemicarbazides prepared from the corresponding acylhydrazides undergo effi

Cyclodesulfurization of Substituted Thiosemicarbazides into 1,3,4-Oxadiazoles via Hydrazonoyl Chlorides

The reaction of thiosemicarbazides 1a-h with hydrazonoyl chlorides 2a-g at ambient temperature, in the presence of triethylamine yielded, in each case, two products. The structure of these compounds was confirmed as 1,3,4-oxadiazoles 14a-h and hydrazonoth

A new and efficient synthesis of 1,3,4-oxadiazole derivatives using TBTU

An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from isothiocyanates and hydrazides through cyclodesulfurization in the presence of (O-(benzotriazol-1-yl)-N,N,N′, N′-tetramethyluronium tetrafluoroborate) TBTU as an uronium cou

Hypervalent iodine(V) mediated mild and convenient synthesis of substituted 2-amino-1,3,4-oxadiazoles

A simple protocol for the synthesis of 2-amino-1,3,4-oxadiazoles starting from the corresponding acylhydrazides by cyclodesulfurization of intermediate acylthiosemicarbazides mediated by o-iodoxybenzoic acid in good yields has been described. The protocol

Electrochemically initiated oxidative cyclization: A versatile route for the synthesis of 5-substituted 2-amino-1,3,4-oxadiazoles

A rapid, improved, and environmentally benign synthesis of 5-substituted 2-amino-1,3,4-oxadiazoles by one-pot electrocyclization of acylthiosemicarbazones is reported. Controlled potential electrolysis was performed at room temperature in acetonitrile as

Synthesis of 2-amino-1,3,4-oxadiazoles from isoselenocyanates via cyclodeselenization

An efficient one-pot method to access 2-amino-1,3,4-oxadiazoles from isoselenocyanates and hydrazides or dihydrazides was developed via cyclodeselenization. Without any harsh reagents, various 2-amino-1,3,4- oxadiazoles were obtained in considerably high

Tetrazoles: LV. Perparation of 2-anilino-5-aryl(hetaryl)-1,3,4-oxadiazoles from 5-substituted tetrazoles under microwave activation

In reaction of 5-aryl(hetaryl)tetrazoles with phenyl isocyanate under the conditions of microwave activation the corresponding 2-anilino-5-aryl(hetaryl)- 1,3,4-oxadiazoles formed in high yields. The application of the microwave activation fourfold reduced

Synthesis and anticonvulsant activity of substituted oxadiazole and thiadiazole derivatives

A series of five membered heterocyclics was synthesized by the reaction between isoniazid and various substituted isothiocyanates and was tested for their anticonvulsant activity by determining their ability to provide protection against convulsions induc

Efficient one-pot synthesis of substituted 2-amino-1,3,4-oxadiazoles

A convenient one-pot method for the preparation of substituted 2-amino-1,3,4-oxadiazoles has been developed. The method is a significant improvement over previously reported syntheses. Reaction of carboxylic acids with thiosemicarbazides afforded the corresponding oxadiazoles in moderate to good yields. In general, the products precipitated from the reaction mixture, and were collected by filtration. In most of the cases, no chromatographic separations were required. To explore the scope and limitations of this reaction, various aliphatic, aromatic, and heteroaromatic carboxylic acids were reacted with different substituted thiosemicarbazides. The influence of R1 and R2 substituents on the reaction yield and additional results demonstrating the versatility of this method are presented.