16175-67-0

Basic information

• Product Name: 2-AMINO-6,7-DIMETHOXYQUINAZOLIN-4-OL
• Synonyms: 2-AMINO-6,7-DIMETHOXYQUINAZOLIN-4-OL;2-Amino-6,7-dimethoxy-4(1H)-quinazolinone;2-amino-6,7-dimethoxy-1H-quinazolin-4-one;4(3H)-Quinazolinone, 2-amino-6,7-dimethoxy-;2-amino-6,7-dimethoxy-3,4-dihydroquinazolin-4-one
• CAS NO: 16175-67-0
• Molecular Formula: C10H11N3O3
• Molecular Weight: 221.22
• Mol File: 16175-67-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 420.9±55.0 °C(Predicted)
• Appearance: /
• Density: 1.46±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.00±0.20(Predicted)
• CAS DataBase Reference: 2-AMINO-6,7-DIMETHOXYQUINAZOLIN-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-6,7-DIMETHOXYQUINAZOLIN-4-OL(16175-67-0)
• EPA Substance Registry System: 2-AMINO-6,7-DIMETHOXYQUINAZOLIN-4-OL(16175-67-0)

Safety Data

• Hazardous Substances Data: 16175-67-0(Hazardous Substances Data)

Usage

General Description

2-Amino-6,7-dimethoxyquinazolin-4-ol is a type of organic compound that falls within the classification of chemicals known as Quinazolines. 2-AMINO-6,7-DIMETHOXYQUINAZOLIN-4-OL is primarily composed of carbon, hydrogen, nitrogen, and oxygen atoms arranged in a specific molecular structure, consisting of two rings, one aromatic (quinazoline) and one non-aromatic. It has potential applications in a variety of fields such as pharmacology and organic synthesis due to its unique chemical properties. However, it's important to note that detailed information about its bioactivity, safety, or detailed applications may not be widely available and should be researched deeper for specific uses.

Upstream product

• 420-04-2 CYANAMID 
• 26759-46-6 methyl 2-amino-4,5-dimethoxybenzoate 
• 5653-40-7 2-Amino-4,5-dimethoxybenzoic acid 
• 21560-74-7 2-(ethoxycarbonylamino)-4,5-dimethoxybenzoic acid 
• 20197-92-6 6,7-dimethoxy-1H-benzo[d][1,3]oxazine-2,4-dione 
• 4338-95-8 S-methylthiouronium iodide 

Downstream Products

• 221698-39-1 2-amino-4-chloro-6,7-dimethoxyquinazoline 

Relevant articles and documents

Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor

4-(3-Bromoanilino)-6,7-dimethoxyquinazoline (32, PD 153035) is a very potent inhibitor (IC50 0.025 nM) of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR), binding competitively at the ATP site. Structure-activity relationships for close analogues of 32 are very steep. Some derivatives have IC50s up to 80-fold better than predicted from simple additive binding energy arguments, yet analogues possessing combinations of similar phenyl and quinazoline substituents do not show this 'supra-additive' effect. Because some substituents which are mildly deactivating by themselves can be strongly activating when used in the correct combinations, it is proposed that certain substituted analogues possess the ability to induce a change in the conformation of the receptor when they bind. There is some bulk tolerance for substitution in the 6- and 7-positions of the quinazoline, so that 32 is not the optimal inhibitor for the induced conformation. The diethoxy derivative 56 [4-(3-bromoanilino)- 6,7-diethoxy-quinazoline] shows an IC50 of 0.006 nM, making it the most potent inhibitor of the tyrosine kinase activity of the EGFR yet reported.

Antihypertensive 2-amino-4(3H)-quinazolinones.

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