161777-76-0

Basic information

• Product Name: 3-[3-[2-(4-Chlorophenylsulfonamido)ethyl]-5-(4-fluorobenzyl)phenyl]propionic acid
• Synonyms: UK-147535
• CAS NO: 161777-76-0
• Molecular Formula: C₂₄H₂₃ClFNO₄S
• Molecular Weight: 475.97061
• Mol File: 161777-76-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 643.9±65.0 °C(Predicted)
• Density: 1.334±0.06 g/cm3(Predicted)
• PKA: 4.67±0.10(Predicted)
• CAS DataBase Reference: 3-[3-[2-(4-Chlorophenylsulfonamido)ethyl]-5-(4-fluorobenzyl)phenyl]propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[3-[2-(4-Chlorophenylsulfonamido)ethyl]-5-(4-fluorobenzyl)phenyl]propionic acid(161777-76-0)
• EPA Substance Registry System: 3-[3-[2-(4-Chlorophenylsulfonamido)ethyl]-5-(4-fluorobenzyl)phenyl]propionic acid(161777-76-0)

Safety Data

• Hazardous Substances Data: 161777-76-0(Hazardous Substances Data)

Usage

Class

Different sources of media describe the Class of 161777-76-0 differently. You can refer to the following data:
1. Propionic acid derivatives
2. Non-steroidal anti-inflammatory drugs (NSAIDs)

Explanation

Different sources of media describe the Explanation of 161777-76-0 differently. You can refer to the following data:
1. Compounds containing a propionic acid derivative
2. Have analgesic, anti-inflammatory, and antipyretic effects

Function

Selective inhibitor of the enzyme diacylglycerol O-acyltransferase 1

Potential therapeutic applications

Treatment of obesity and type 2 diabetes

Need for further research

To fully understand its pharmacological properties and potential therapeutic applications

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 810681-06-2 3-bromo-5-iodobenzoyl chloride 
• 188815-32-9 3-bromo-5-iodo-benzoic acid 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 161777-75-9 ethyl 3-[2-[(4-chlorophenyl)sulphonylamino]ethyl]-5-[(4-fluorophenyl)methyl]benzenepropanoate 
• 214406-52-7 (E)-3-{3-((E)-2-Ethoxycarbonyl-vinyl)-5-[(4-fluoro-phenyl)-hydroxy-methyl]-phenyl}-acrylic acid ethyl ester 
• 161811-95-6 Diethyl 5-[(4-fluorophenyl)methyl],1,3-benzene-dipropanoate 
• 161778-30-9 monoethyl 5-[(4-fluorophenyl)methyl]-1,3-benzenedipropanoate 
• 161777-98-6 3,5-dibromo-α-(4-fluorophenyl)benzenemethanol 
• 626-39-1 1,3,5-trisbromobenzene 
• 161778-35-4 ethyl 3-(2-carbamoylethyl)-5-[(4-fluorophenyl)methyl]-benzenepropanoate 

Relevant articles and documents

Thromboxane modulating agents. 4. Design and synthesis of 3-(2-[{(4- chlorophenyl)sulfonyl}-amino]ethyl)benzenepropanoic acid derivatives as potent thromboxane receptor antagonists

The design of a series of thromboxane receptor antagonists based on 3- (2-[{(4-chlorophenyl)sulfonyl}amino]ethyl)benzenepropanoic acid (1) is described. Addition of an arylmethyl group at the 5-position of 1 gave exceptionally potent agents in vitro and in vivo, with 13a (UK-147,535) giving complete blockade of the TxA2 receptor for greater than 12 hours in dogs, following an oral dose of 0.1 mg/kg.

BENZENEALKANOIC ACIDS FOR CARDIOVASCULAR DISEASES

Compounds of formula (I) wherein R 1, R 2, R 3 and R 4 are each H or C 1-C 4 alkyl; R 5 is (CH 2) m NHSO. sub.2 R 6 or (CH) m NHCOR 6 ; R 6 is C 1-C 6 alkyl, C 3-C 6 cycloalkyl optionally substituted by aryl, aryl or heteroaryl; R 7 is H, C 1-C 4 alkyl, C