1618101-67-9Relevant academic research and scientific papers
Unexpected lateral-lithiation-induced alkylative ring opening of tetrahydrofurans in deep eutectic solvents: Synthesis of functionalised primary alcohols
Sassone, Francesca C.,Perna, Filippo M.,Salomone, Antonio,Florio, Saverio,Capriati, Vito
, p. 9459 - 9462 (2015/06/08)
o-Tolyl-substituted tetrahydrofurans undergo highly regioselective ring opening with the concomitant formation of new C-C bonds as the result of a lateral lithiation reaction. This reaction provides a new method for the synthesis of functionalised primary
Regioselective desymmetrization of diaryltetrahydrofurans via directed ortho-lithiation: An unexpected help from green chemistry
Mallardo, Valentina,Rizzi, Ruggiero,Sassone, Francesca C.,Mansueto, Rosmara,Perna, Filippo M.,Salomone, Antonio,Capriati, Vito
, p. 8655 - 8658 (2014/07/22)
An efficient functionalization of diaryltetrahydrofurans via a regioselective THF-directed ortho-lithiation is first described. This reaction can be successfully carried out in cyclopentyl methyl ether as a greener alternative to Et2O, with better results in terms of yield and selectivity and, surprisingly, also in protic eutectic mixtures competitively with protonolysis.
