161832-65-1 Usage
Description
Talampanel, also known as a potent and selective AMPA antagonist, is a pharmaceutical compound that has been developed for its potential therapeutic applications. It is characterized by its ability to selectively block the AMPA receptors, which play a crucial role in the transmission of neuronal signals. This selective action makes Talampanel a promising candidate for various medical applications, particularly in the treatment of neurological disorders.
Uses
Used in Pharmaceutical Industry:
Talampanel is used as an antiepileptic drug for the treatment of epilepsy. Its selective action on AMPA receptors helps in reducing the frequency and severity of seizures, providing relief to patients suffering from this neurological condition. By modulating the excitatory neurotransmission, Talampanel contributes to the regulation of neuronal activity and offers a targeted approach to epilepsy management.
Additionally, due to its potent and selective nature, Talampanel may also hold potential in other neurological applications, such as the treatment of other seizure-related disorders or conditions involving excessive neuronal excitation. However, further research and clinical trials are necessary to explore these possibilities and establish the safety and efficacy of Talampanel in these contexts.
Check Digit Verification of cas no
The CAS Registry Mumber 161832-65-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,1,8,3 and 2 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 161832-65:
(8*1)+(7*6)+(6*1)+(5*8)+(4*3)+(3*2)+(2*6)+(1*5)=131
131 % 10 = 1
So 161832-65-1 is a valid CAS Registry Number.
InChI:InChI=1/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1
161832-65-1Relevant articles and documents
Sassafras oil, carrot bits and microwaves: Green lessons learned from the formal total synthesis of (-)-talampanel
Omori, Alvaro Takeo,De Oliveira, Camila De Souza,Andrade, Kleber Tellini,Capeletto, Marina Gon?alves
, p. 103563 - 103565 (2015/12/23)
A formal total synthesis of (-)-talampanel (1), a 2,3-benzodiazepine is described. This work was undertaken to utilize greener reaction conditions. Safrole (a renewable source) was converted to (1) in eight steps, including an enantioselective bioreduction using carrots as the key step. Microwave irradiation was also used to perform three reaction steps.
Physical form of dihydro-2,3-benzodiazepine derivative
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, (2008/06/13)
A physical form of (R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine having an X-ray powder diffraction pattern with d spacings at 10.61, 8.83, 6.78, 5.83, 4.13 and 3.74 ?. The compound is useful as an AMPA antag
STEREOSELECTIVE PROCESS FOR PRODUCING DIHYDRO-2,3-BENZODIAZEPINE DERIVATIVES
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, (2008/06/13)
A process for stereoselectively forming N-substituted dihydro-2,3 benzodiazepines which are useful as AMPA receptor antagonists. The process includes an opening reduction step which sets the stereochemistry of the intermediates and the final compounds to