196303-02-3

Upstream product

• 4676-39-5 1-(1,3-benzodioxol-5-yl)-2-propanone 
• 94-59-7 1-allyl-3,4-methylenedioxybenzene 
• 172542-26-6 (S)-α-methyl-1,3-benzodioxole-5-ethanol 
• 196303-01-2 isochroman 

Downstream Products

• 178751-09-2 (S)-1-{6-[(4-Nitro-phenyl)-(pyridin-2-yl-hydrazono)-methyl]-benzo[1,3]dioxol-5-yl}-propan-2-ol 
• 211732-82-0 Methanesulfonic acid (S)-1-methyl-2-{6-[(4-nitro-phenyl)-(phthalazin-1-yl-hydrazono)-methyl]-benzo[1,3]dioxol-5-yl}-ethyl ester 
• 211732-83-1 Methanesulfonic acid (S)-2-{6-[(benzothiazol-2-yl-hydrazono)-(4-nitro-phenyl)-methyl]-benzo[1,3]dioxol-5-yl}-1-methyl-ethyl ester 
• 211732-80-8 Methanesulfonic acid (S)-1-methyl-2-{6-[(4-nitro-phenyl)-(phenyl-hydrazono)-methyl]-benzo[1,3]dioxol-5-yl}-ethyl ester 
• 211732-81-9 Methanesulfonic acid (S)-1-methyl-2-{6-[(4-nitro-phenyl)-(pyridin-2-yl-hydrazono)-methyl]-benzo[1,3]dioxol-5-yl}-ethyl ester 
• 178751-20-7 (R)-7-(2-benzimidazolyl)-8,9-dihydro-8-methyl-5-(4-nitrophenyl)-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine 
• 178751-14-9 (R)-7-(1-phthalazinyl)-8,9-dihydro-8-methyl-5-(4-nitrophenyl)-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine 
• 178751-18-3 (R)-7-(2-benzothiazolyl)-8,9-dihydro-8-methyl-5-(4-nitrophenyl)-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine 

Relevant academic research and scientific papers

Sassafras oil, carrot bits and microwaves: Green lessons learned from the formal total synthesis of (-)-talampanel

A formal total synthesis of (-)-talampanel (1), a 2,3-benzodiazepine is described. This work was undertaken to utilize greener reaction conditions. Safrole (a renewable source) was converted to (1) in eight steps, including an enantioselective bioreduction using carrots as the key step. Microwave irradiation was also used to perform three reaction steps.

STEREOSELECTIVE PROCESS FOR PRODUCING DIHYDRO-2,3-BENZODIAZEPINE DERIVATIVES

A process for stereoselectively forming N-substituted dihydro-2,3 benzodiazepines which are useful as AMPA receptor antagonists. The process includes an opening reduction step which sets the stereochemistry of the intermediates and the final compounds to