176777-96-1Relevant articles and documents
Sassafras oil, carrot bits and microwaves: Green lessons learned from the formal total synthesis of (-)-talampanel
Omori, Alvaro Takeo,De Oliveira, Camila De Souza,Andrade, Kleber Tellini,Capeletto, Marina Gon?alves
, p. 103563 - 103565 (2015/12/23)
A formal total synthesis of (-)-talampanel (1), a 2,3-benzodiazepine is described. This work was undertaken to utilize greener reaction conditions. Safrole (a renewable source) was converted to (1) in eight steps, including an enantioselective bioreduction using carrots as the key step. Microwave irradiation was also used to perform three reaction steps.
Application of a practical biocatalytic reduction to an enantioselective synthesis of the 5H-2,3-benzodiazepine LY300164
Anderson, Benjamin A.,Hansen, Marvin M.,Harkness, Allen R.,Henry, Cynthia L.,Vicenzi, Jeffrey T.,Zmijewski, Milton J.
, p. 12358 - 12359 (2007/10/03)
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