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16185-96-9

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16185-96-9 Usage

General Description

2'-(Trifluoromethyl)propiophenone is a chemical compound with the molecular formula C10H8F3NO. It is a yellow liquid with a strong aromatic odor and is mainly used as an intermediate in organic synthesis. Its main applications include being used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a reagent in the production of various other chemicals. Additionally, it is known for its strong oxidizing properties and is often used in analytical chemistry and biochemical research. However, it is important to handle and store this chemical with care due to its flammability and potential health hazards.

Check Digit Verification of cas no

The CAS Registry Mumber 16185-96-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,1,8 and 5 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 16185-96:
(7*1)+(6*6)+(5*1)+(4*8)+(3*5)+(2*9)+(1*6)=119
119 % 10 = 9
So 16185-96-9 is a valid CAS Registry Number.
InChI:InChI=1/C10H9F3O/c1-2-9(14)7-5-3-4-6-8(7)10(11,12)13/h3-6H,2H2,1H3

16185-96-9 Well-known Company Product Price

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  • Alfa Aesar

  • (A17713)  2'-(Trifluoromethyl)propiophenone, 97%   

  • 16185-96-9

  • 1g

  • 300.0CNY

  • Detail
  • Alfa Aesar

  • (A17713)  2'-(Trifluoromethyl)propiophenone, 97%   

  • 16185-96-9

  • 5g

  • 1130.0CNY

  • Detail

16185-96-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2'-(Trifluoromethyl)propiophenone

1.2 Other means of identification

Product number -
Other names 1-[2-(trifluoromethyl)phenyl]propan-1-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:16185-96-9 SDS

16185-96-9Relevant articles and documents

Preparation of Trifluoromethylphenyl Magnesium Halides in the Presence of LiCl and Synthesis of 2′-Trifluoromethyl-Aromatic Ketones

Nakatani, Jiro,Nozoe, Tatsuhiro

, p. 1633 - 1636 (2016)

The effect of LiCl-promoted insertion of magnesium turnings into halogenated-trifluoromethylbenzenes for Grignard reagent synthesis was investigated. In the presence of less than 1.0 equiv of LiCl, chloro(trifluoromethyl)benzene Grignard reagents were easily generated. The 2-trifluoromethylphenyl magnesium chloride Grignard reagent was obtained in high yield and 2′-trifluoromethyl-substituted aromatic ketone was synthesized through reaction of the obtained Grignard reagent with a carboxylic anhydride in an 83% yield.

METHOD OF PRODUCING 2'-TRIFLUOROMETHYL GROUP-SUBSTITUTED AROMATIC KETONE

-

Paragraph 0042; 0043; 0044; 0045; 0048; 0052, (2017/04/18)

A method produces a 2′-trifluoromethyl-substituted aromatic ketone and includes reacting a 2-halogen-substituted benzotrifluoride compound with magnesium metal to convert the compound to a Grignard reagent; and reacting the Grignard reagent with an acid anhydride; and then hydrolyzing the resultant to produce a 2′-trifluoromethyl-substituted aromatic ketone. The method of producing a 2′-trifluoromethyl-substituted aromatic ketone enables 2′-trifluoromethyl-substituted aromatic ketone to be produced without using expensive raw materials by generating a Grignard reagent as an intermediate and reacting this Grignard reagent with an acid anhydride in an efficient productivity. The 2′-trifluoromethyl-substituted aromatic ketone that is produced by the method of producing a 2′-trifluoromethyl-substituted aromatic ketone can be used as fine chemicals, raw materials for pharmaceuticals and agrochemicals, raw materials for resins and plastics, electronics and information related materials, optical materials, and the like.

Synthesis and activity of 2-methyl-3-aminopropiophenones as centrally acting muscle relaxants

Shiozawa,Narita,Izumi,Kurashige,Sakitama,Ishikawa

, p. 85 - 94 (2007/10/02)

Some novel 2-methyl-3-aminopropiophenones were synthesized and their centrally acting muscle relaxant activities were,evaluated for an inhibitory effect on the flexor reflex in rats. The structure-activity relationships are discussed. In this series 2-methyl-3-pyrrolidino-1-(4-trifluoromethylphenyl)-propan-1-one (28) showed significant centrally acting muscle relaxant activity. In addition, the activities of each enantiomer (28-(S) and (R)) were studied along with their acute toxicities. Compound 28-(R) was found to exhibit more potent activity and weaker acute toxicity than 28-(S). Accordingly, compound 28-(R) (NK433) is under development as a novel centrally acting muscle relaxant.

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