161855-69-2

Upstream product

• 123-56-8 Succinimide 
• 4596-53-6 N-[[(4-Nitrophenyl)methoxy]carbonyl]glycine 
• 158556-65-1 4-nitrophenyl (4-nitrophenyl)methyl carbonate 
• 4457-32-3 4-nitrobenzyl chloroformate 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 

Downstream Products

• 726201-90-7 diphenylmethyl p-nitrobenzyl 7-[N-(p-nitrobenzyloxycarbonyl)glycyl-L-α-aminopimelyl]aminocephalosporanate 
• 726201-89-4 bis(p-nitrobenzyl) 6-[N-(p-nitrobenzyloxycarbonyl)glycyl-L-α-aminopimelyl]aminopenicillanate 
• 726201-91-8 p-nitrobenzyl 7-[N-(p-nitrobenzyloxycarbonyl)glycyl-L-α-aminopimelyl]aminocephalosporanic acid 
• 726201-88-3 p-nitrobenzyl N-(p-nitrobenzyloxycarbonyl)glycyl-L-α-aminopimelate 
• 726201-87-2 N-(p-nitrobenzyloxycarbonyl)glycyl-L-α-aminopimelic acid 

Relevant academic research and scientific papers

The perfect penicillin? Inhibition of a bacterial DD-peptidase by peptidoglycan-mimetic β-lactams

6-(Glycyl-L-α-aminopimelyl)-aminopenicillanic acid and 7-(glycyl-L-α-aminopimelyl)-aminocephalosporanic acid have been synthesized as Streptomyces sp. peptidoglycan-mimetic β-lactams. These compounds inactivate the Streptomyces R61 DD-peptidase with rate

Peptidic prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Peptidic prodrugs of the five most active aminomethyl-THF β- methylcarbapenems were synthesized. Of these, only L-amino acid derivatives from la demonstrated an improved oral activity. These results indicate that the L-amino acid derivatives from la are orally absorbed most likely through the dipeptide and tripeptide transport mechanism.

2-thiosubstituted carbapenems

Carbapenem antibiotic compounds of the general formula: STR1 wherein the moiety STR2 is a 4, 5 or 6 membered mono, di- or tri- substituted oxygen or sulfur containing ring; wherein Z is oxygen, sulfur, sulfoxide and sulfone, pharmaceutical compositions thereof useful for the treatment of bacterial infections, processes for preparing the compounds and new intermediates useful in the process.