16188-40-2Relevant articles and documents
Synthesis method of high-purity bacteriostatic agent and derivatives thereof
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Paragraph 0047; 0073-0075, (2020/04/29)
The invention discloses a synthesis method of a high-purity bacteriostatic agent and derivatives thereof. The synthesis method comprises the following specific steps: adding primary amine or secondaryamine into a solvent, adding perchloromethyl mercaptan, reacting at room temperature for 14-18 hours, washing the reaction solution with water, separating, drying, concentrating the solvent and separating to obtain an intermediate 1; mixing the intermediate 1 with a solvent and fluoride, heating to 100-140 DEG C, reacting for 6-18 hours, filtering the reaction solution, washing with water, drying, concentrating the solvent, rectifying and separating to obtain an intermediate 2; mixing the intermediate 2 with a solvent, introducing hydrogen chloride gas at 0-10 DEG C to react for 2-16 hours, washing the reaction solution with water, separating, drying and concentrating the solvent to obtain an intermediate 3; and mixing the intermediate 4 with a solvent, adding alkali at 0-10 DEG C, reacting for 0.5-1 hour, adding the intermediate 3, reacting at room temperature for 1-2 hours, washing the reaction solution with water, separating, drying and concentrating the solvent to obtain the target compound. The method is low in cost and high in product yield and a high-purity product can be obtained.
A-new synthesis of N-sulfinylamines via β-elimination of chloroform from trichloromethanesulfinamides
Braverman, Samuel,Cherkinsky, Marina
, p. 487 - 490 (2007/10/03)
The synthesis of various N-monosubstituted trichloromethanesulfinamides by two alternative and novel procedures is described. All these compounds have been found to undergo base-induced elimination of chloroform with formation of the corresponding N-sulfinylamines. Reaction proceeds smoothly under mild conditions.
