16188-40-2

Upstream product

• 106-49-0 p-toluidine 
• 594-42-3 chlorothio-trichloro-methane 
• 3204-37-3 5,5-dimethyl-3-trichloromethylsulfanyl-imidazolidine-2,4-dione 

Downstream Products

• 47459-89-2 N,N',N''-tris(4-methylphenyl)guanidine 
• 137838-63-2 2,3-bis(4-methylphenyl)-5,5,6,6-tetrachloro-2,3,5,6-tetrahydro-1,4,2,3-dithiadiazine 
• 187835-87-6 Trichloro-methanesulfinic acid p-tolylamide 
• 124-38-9 carbon dioxide 
• 7783-06-4 hydrogen sulfide 
• 540-23-8 p-toluidine hydrochloride 
• 622-59-3 1-isothiocyanato-4-methylbenzene 
• 24215-01-8 N-(diphenylmethylene)-p-toluidine 
• 15795-42-3 N-sulfinyl-4-methylaniline 
• 18715-75-8 2,5-Bis-(p-tolyl)-3,3,6,6-tetrachlor-tetrahydro-1,4,2,5-dithiadiazin 

Relevant academic research and scientific papers

Synthesis method of high-purity bacteriostatic agent and derivatives thereof

The invention discloses a synthesis method of a high-purity bacteriostatic agent and derivatives thereof. The synthesis method comprises the following specific steps: adding primary amine or secondaryamine into a solvent, adding perchloromethyl mercaptan, reacting at room temperature for 14-18 hours, washing the reaction solution with water, separating, drying, concentrating the solvent and separating to obtain an intermediate 1; mixing the intermediate 1 with a solvent and fluoride, heating to 100-140 DEG C, reacting for 6-18 hours, filtering the reaction solution, washing with water, drying, concentrating the solvent, rectifying and separating to obtain an intermediate 2; mixing the intermediate 2 with a solvent, introducing hydrogen chloride gas at 0-10 DEG C to react for 2-16 hours, washing the reaction solution with water, separating, drying and concentrating the solvent to obtain an intermediate 3; and mixing the intermediate 4 with a solvent, adding alkali at 0-10 DEG C, reacting for 0.5-1 hour, adding the intermediate 3, reacting at room temperature for 1-2 hours, washing the reaction solution with water, separating, drying and concentrating the solvent to obtain the target compound. The method is low in cost and high in product yield and a high-purity product can be obtained.

Generation and selected reactions of chlorinated thiocarbonyl S-imides*

N-Aryl-1,1,1-trichloromethanesulfenamides ArNH-SCCl3 easily undergo dehydrochlorination upon treatment with potassium hydroxide in ethanolic solution. The intermediate thiocarbonyl S-imides formed thereby behave differently depending on the typ

A-new synthesis of N-sulfinylamines via β-elimination of chloroform from trichloromethanesulfinamides

The synthesis of various N-monosubstituted trichloromethanesulfinamides by two alternative and novel procedures is described. All these compounds have been found to undergo base-induced elimination of chloroform with formation of the corresponding N-sulfinylamines. Reaction proceeds smoothly under mild conditions.

In Search of New Sulfur Transfer Agents

The chemistry of various sulfur-transfer agents is studied.The reaction of aromatic sulfenyl chloride 5 in the presence of imidazole and/or triethylamine gives the aryl disulfides 7 in 14-85 percent yield, whereas in the case of the corresponding benzylsulfenyl chlorides 9 in the presence of triethylamine and/or caprolactam, both disulfide 10 and benzyl chlorides 11 are formed in 0-81 precent and 10-72 precent yield, respectively. - The transfer reactions of 3-sulfenylated hydantoins 18 with amines are useful for the preparation of the unsymmetric sulfenamides 20 in 31 -61 percent yield.Analogous transfer reactions of compounds 23 and 24 with piperidine give N,N'-thiodipiperidine (3, X = CH2) in 71-80 percent.