16190-65-1Relevant academic research and scientific papers
Spiro-annulation of barbituric acid derivatives and its analogs by ring-closing metathesis reaction
Kotha, Sambasivarao,Deb, Ashoke Chandra,Kumar, Ramanatham Vinod
, p. 1039 - 1043 (2005)
Barbituric acid 1 and related β-dicarbonyl compounds were dialkenylated under the phase-transfer catalyst [e.g., benzyltriethylammonium chloride (BTEAC)] conditions to generate the diallylated products. These diallylated products were subjected to the ring-closing metathesis (RCM) reaction to deliver the corresponding spiro-annulated derivatives.
Design and synthesis of spiro-heterocycles by ring-closing metathesis
Kotha, Sambasivarao,Deb, Ashoke Chandra
, p. 1120 - 1134 (2008/12/23)
Synthesis of diverse spiro-heterocyclic compounds via the ring-closing (RCM) metathesis approach is described. Specifically, synthesis of various derivatives of barbituric acid, Meldrum's acid, tetronic acid and thiotetronic acid are described by RCM approach.
