161925-43-5

Upstream product

• 161973-00-8 (2S,4E,6S,7R,8S)-8-benzyloxy-1-(methoxymethoxy)-7-phenylthio-2,4,6-trimethylnon-4-ene 
• 161925-48-0 (2S,4E,6S,8S)-8-benzoyloxy-1-(methoxymethoxy)-2,4,6-trimethylnon-4-ene 
• 161925-49-1 (2S,4E,6S,8S)-8-benzoyloxy-2,4,6-trimethylnon-4-en-1-ol 
• 98-88-4 benzoyl chloride 
• 161925-50-4 (2S,4E,6S,8S)-8-benzoyloxy-2,4,6-trimethylnon-4-en-1-al 
• 161925-47-9 (2S,4E,6S,8S)-8-hydroxy-1-(methoxymethoxy)-2,4,6-trimethylnon-4-ene 

Downstream Products

• 119717-37-2 jasplakinolide 
• 161925-59-3 jaspamide Z₁ 
• 161925-58-2 methyl (3R,6R,9S,12S,14E,16R,18S)-6-<(2-bromo-1H-indol-3-yl)methyl>-18-benzoyloxy-3-<4-(tert-butyldimethylsilyloxy)phenyl>-7,9,12,14,16-pentamethyl-5,8,11-trioxo-4,7,10-triazanonadeca-14-enoate 

Relevant academic research and scientific papers

A synthesis of Jaspamide based on 1,2-metallate rearrangements of α-heteroalkenylmetal derivatives

Jaspamide (Jasplakinolide), a marine cyclodepsipeptide, was synthesised from tripeptide fragment 4 and (2S,4E,6R,8S)-8-benzoyloxy-2,4,6-trimethylnon-4-enoic acid (3). The tripeptide fragment was prepared from β-tyrosine derivative 6, Boc-2-bromoabrine (8)

New β-Amino Alcohols Derived from L-Valine as Chiral Inductors for Enantioselective Reductions of, and Nucleophilic Additions to Carbonyl Compounds

β-Amino alcohols derived from L-valine were used as chiral ligands in oxazaborolidine reductions of ketones.Structural modifications, such as the introduction of alkyl groups on the carbinol carbon and the nitrogen atoms, were shown to influence unfavourably the enantioselectivity.In contrast, the addition of diethyl zinc to aldehydes occurs with enhanced e.e.'s using this modified inductors, which permit to reach useful enantioselectivities with various aldehydes.