161957-57-9

Basic information

• Product Name: 1-(2-Chloro-3-fluorophenyl)ethanone
• Synonyms: 1-(2-Chloro-3-fluorophenyl)ethanone
• CAS NO: 161957-57-9
• Molecular Formula: C8H6ClFO
• Molecular Weight: 172.5840432
• Mol File: 161957-57-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 205℃
• Flash Point: 78℃
• Appearance: /
• Density: 1.258
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2-Chloro-3-fluorophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Chloro-3-fluorophenyl)ethanone(161957-57-9)
• EPA Substance Registry System: 1-(2-Chloro-3-fluorophenyl)ethanone(161957-57-9)

Safety Data

• Hazardous Substances Data: 161957-57-9(Hazardous Substances Data)

Usage

Uses

1-(2-Chloro-3-fluorophenyl)ethanone was used to prepare novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases.

InChI:InChI=1S/C8H6ClFO/c1-5(11)6-3-2-4-7(10)8(6)9/h2-4H,1H3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 102940-86-3 3-chloro-3-fluorobenzoic acid 
• 1286776-24-6 2-chloro-3-fluoro-N-methoxy-N-methylbenzamide 
• 676-58-4 methylmagnesium chloride 
• 455-38-9 3-fluorobenzoic acid 
• 917-54-4 methyllithium 

Downstream Products

• 1624606-87-6 (S)-tert-butyl 3-(2-chloro-3-fluorophenyl)-3-((R)-1,1-dimethylethylsulfinamido) butanoate 

Relevant articles and documents

Iminothiadiazine Dioxide Compounds as BACE Inhibitors, Compositions and Their Use

In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R1, R2, R3, R4, R5, R9, ring A, ring B, m, n, p, -L1-, -L2-, and -L3- is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to β-amyloid (“Aβ”) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimer's disease, are also disclosed.

Lithiations directed by carboxylic acid, fluorine and chlorine: The regioselective synthesis of polysubstituted benzoic acids and acetophenones

Lithiation/electrophilic quenching of ortho-lithiated benzoates allows the totally regiocontrolled synthesis of a wide range of 2,3-, 2,3,4-, and 2,3,4,5-polysubstituted benzoic acids and related acetophenones. Elsevier,.