161975-22-0

Usage

Uses

Used in Organic Synthesis:
4-BENZYLOXY-THIOBENZAMIDE is used as a building block in organic synthesis for its reactivity and versatility, allowing chemists to create a variety of new molecules with potential applications in various industries.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-BENZYLOXY-THIOBENZAMIDE is utilized as a key component in the development of pharmaceutical compounds. Its unique structure and properties make it a promising candidate for the synthesis of new drugs with potential therapeutic effects.
Used in Pharmaceutical Industry:
4-BENZYLOXY-THIOBENZAMIDE is used as a precursor in the pharmaceutical industry for the synthesis of various drug molecules. Its characteristic properties enable the creation of compounds with specific biological activities, contributing to the development of innovative treatments for a range of diseases.
Used in Industrial Applications:
Beyond its use in medicine, 4-BENZYLOXY-THIOBENZAMIDE also finds applications in other industries, such as the development of new materials with unique properties, including those used in chemical manufacturing processes or as components in various products.

Upstream product

• 76193-67-4 4-benzyloxybenzaldehyde oxime 
• 52805-36-4 4-benzyloxybenzonitrile 
• 100-39-0 benzyl bromide 
• 767-00-0 4-cyanophenol 

Downstream Products

• 1236827-20-5 3,5-bis(4-benzyloxyphenyl)[1,2,4]thiadiazole 
• 1415596-14-3 C₂₅H₂₂ClNO₂S 
• 1415596-30-3 C₃₂H₃₇ClN₂O₂S 
• 1415596-28-9 C₃₃H₃₇ClN₂O₂S 
• 1415596-38-1 C₃₂H₃₅ClN₂O₂S 
• 1415596-40-5 C₃₃H₃₇ClN₂O₂S 
• 1415596-42-7 C₃₃H₃₈ClN₃O₂S 
• 1415596-44-9 C₃₂H₃₅ClN₂O₃S 
• 1415596-47-2 C₃₀H₃₃ClN₂O₂S 
• 1415596-49-4 C₃₁H₃₃ClN₂O₂S 
• 1415596-51-8 C₃₂H₃₅ClN₂O₂S 
• 1415596-54-1 C₃₁H₃₃ClN₂O₃S 
• 1415596-56-3 C₂₉H₃₁ClN₂O₂S 
• 1415596-58-5 C₃₁H₃₅ClN₂O₂S 

Relevant academic research and scientific papers

Design and optimization of hybrid of 2,4-diaminopyrimidine and arylthiazole scaffold as anticancer cell proliferation and migration agents

Therapeutics of metastatic or triple-negative breast cancer are still challenging in clinical. Herein we demonstrated the design and optimization of a series of hybrid of 2,4-diaminopyrimidine and arylthiazole derivatives for their anti-proliferative properties against two breast cancer cell lines (MCF-7 as human breast cancer and MDA-MB-231 as triple-negative breast cancer). More importantly, some of those compounds with potent antiproliferative activities also indicated excellent inhibitory activities against MDA-MB-231 cell migration. These results suggested that the new series of hybridation of aryl-thiazoles and aminopyrimidines could be identified and developed as novel highly potential anticancer agents against the triple-negative breast cancer as well as metastatic one in the future.

A novel process for the synthesis of 3,5-diaryl-1,2,4-thiadiazoles from aryl nitriles

A novel and efficient process for the synthesis of 3,5-diaryl-1,2,4- thiadiazoles from aryl nitriles in 1-butyl-3-methylimidazolium bromide promoted by (NH4)2S and TCT-DMSO is described.

Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease

A series of thiazole derivatives were designed, and prepared to develop RAGE antagonist for the treatment of Alzheimer's disease (AD). SAR studies were performed to optimize inhibitory activity on Aβ-RAGE binding. SAR studies showed that introducing an amino group at part A was essential for inhibitory activity on Aβ-RAGE binding. Compounds selected from Aβ-RAGE binding screening displayed inhibitory activity on Aβ transport across BBB. They also showed inhibitory activity against Aβ-induced NF-κB activation. These results indicated that our derivatives had a potential as therapeutic agent for the treatment of AD.

Efficient and green protocol for the synthesis of thioamides in C 6 (mim)2Cl2 as a dicationic ionic liquid

A simple, efficient, facile and eco-friendly process for the synthesis of thioamides from nitriles using 1,6-bis(3methylimidazolium-1-yl)hexane chloride [C6(mim)2Cl2] as a dicationic ionic liquid (DIL) was developed. The ionic liquid was easily separated from the reaction mixture and was recycled at least four times without any loss of its activity.

TiCl3OTf-[bmim]Br: a novel and efficient catalyst system for chemoselective one-pot synthesis of thioamides from arylaldoximes

The combination of TiCl3OTf with 1-butyl-3-methylimidazolium bromide is found to be an efficient and novel catalytic system for chemoselective one-pot transformation of arylaldoximes to their corresponding thioamides in high to excellent yields.