16199-74-9

Basic information

• Product Name: alpha-cyclohexylthiophen-3-acetic acid
• Synonyms: alpha-cyclohexylthiophen-3-acetic acid;α-Cyclohexyl-3-thiopheneacetic acid;Einecs 240-328-3
• CAS NO: 16199-74-9
• Molecular Formula: C₁₂H₁₆O₂S
• Molecular Weight: 224.31924
• EINECS: 240-328-3
• Mol File: 16199-74-9.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: alpha-cyclohexylthiophen-3-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-cyclohexylthiophen-3-acetic acid(16199-74-9)
• EPA Substance Registry System: alpha-cyclohexylthiophen-3-acetic acid(16199-74-9)

Safety Data

• Hazardous Substances Data: 16199-74-9(Hazardous Substances Data)

Upstream product

• 3193-02-0 (+/-)-2-cyclohexyl-2-hydroxy-2-(3-thienyl)ethanoic acid 
• 58414-52-1 thiophen-3-yl-acetic acid methyl ester 
• 108-85-0 1-bromocyclohexane 
• 2043-61-0 cyclohexanecarbaldehyde 
• 81560-74-9 N-(tert-butyl)-2-cyclohexyl-2-oxoacetamide 
• 4957-67-9 2-cyclohexyl-2-hydroxyethanoic acid N-t-butylamide 
• 4354-49-8 2-cyclohexyl-2-oxoethanoic acid 
• 100007-62-3 2-cyclohexyl-2-hydroxyacetonitrile 
• 37784-63-7 ethyl-3 thiophene acetate 
• 6964-21-2 thiophen-3-yl-acetic acid 
• 953-91-3 cyclohexyl tosylate 
• 51536-25-5 ethyl 2-cyclohexyl-2-(3-thienyl)ethanoate 
• 55504-38-6 Cyclohexyl-thiophen-3-yl-acetic acid methyl ester 

Downstream Products

• 51536-32-4 Cyclohexyl-thiophen-3-yl-acetyl chloride 
• 58414-70-3 (2.5-Dinitro-thienyl-3)-cyclohexyl-acetic acid 
• 58414-69-0 (5-Nitro-thienyl-3)-cyclohexyl-acetic acid 
• 58414-68-9 (2-Bromo-thienyl-3)-cyclohexyl-acetic acid 
• 73812-48-3 2-Cyclohexyl-2-thiophen-3-yl-acetamide 

Relevant articles and documents

Discovery of new C3aR ligands. Part 2: Amino-piperidine derivatives

The synthesis and structure-activity relationships against the C3a receptor of a series of substituted aminopiperidine derivatives are reported. DMPK properties and functional activities of selected compounds are described. The compounds obtained are the first non-arginine ligands of C3aR.

The synthesis and some pharmacological actions of the enantiomers of the K+-channel blocker cetiedil

Cetiedil ((±)-2-cyclohexyl-2-(3-thienyl)ethanoic acid 2-(hexahydro-1H-azepin-1-yl) ethyl ester) possesses anti-sickling and analgesic, antispasmodic, local anaesthetic and vasodilator activities. A total synthesis and circular dichroism spectra of the enantiomers of cetiedil is described, together with a comparison of their effectiveness as blockers of the Ca2+-activated K+ permeability of rabbit erythrocytes; the contractile response of intestinal smooth muscle to acetylcholine; the Ca2+-dependent contraction of depolarized intestinal muscle; and the cell volume-sensitive K+ permeability (K(vol)) of liver cells. The enantiomers did not differ substantially in their ability to block the Ca2+-activated K+ permeability of rabbit red cells or in their effectiveness as blockers of the contractile response of depolarized smooth muscle to externally applied Ca2+. There was a clear difference in the muscarinic blocking activity of the enantiomers, as assessed by inhibition of the contractile response of intestinal smooth muscle to acetylcholine; (+)-cetiedil was 7.7 ± 0.2 (s.d.) times more active than the (-) form. The enantiomers also differed in their potency as blockers of the increase in membrane conductance which occurs when liver cells swell. The concentration of (+)-cetiedil needed to reduce the conductance increase by 50% was 2.04 ± 0.54 (s.d.) μM; (-)-cetiedil was 2.6 ± 0.8 (s.d.) times less active (IC50 of 5.2 ± 1.2 μM). Differences in the biological actions of the enantiomers of cetiedil indicate that a more extensive study could be rewarding in relation to the use of the enantiomers both in therapeutics and in the study of K+ channels.