953-91-3Relevant articles and documents
Identification of organophosphorus simulants for the development of next-generation detection technologies
Ellaby, Rebecca J.,Clark, Ewan R.,Allen, Nyasha,Taylor, Faith R.,Ng, Kendrick K. L.,Dimitrovski, Milan,Chu, Dominique F.,Mulvihill, Daniel P.,Hiscock, Jennifer R.
, p. 2008 - 2014 (2021/03/16)
Organophosphorus (OP) chemical warfare agents (CWAs) represent an ongoing threat but the understandable widespread prohibition of their use places limitations on the development of technologies to counter the effects of any OP CWA release. Herein, we describe new, accessible methods for the identification of appropriate molecular simulants to mimic the hydrogen bond accepting capacity of the PO moiety, common to every member of this class of CWAs. Using the predictive methodologies developed herein, we have identified OP CWA hydrogen bond acceptor simulants for soman and sarin. It is hoped that the effective use of these physical property specific simulants will aid future countermeasure developments.
Pyrazole compound and preparation and application methods thereof
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Paragraph 0053; 0055-0060, (2018/10/19)
The invention provides a pyrazole compound and preparation and application methods thereof. The pyrazole compound is synthesized by introducing 2-amido-benzoxazole groups into pyrazole. The prepared pyrazole compound is low in toxic and side effects, high in oral bioavailability, significant in inhibition on tumor cells such as human breast cancer cells, human lung cancer cells, human prostatic cancer cells, human gastric cancer cells and human malignant glioma cells and capable of providing new possibilities for developing high-efficiency and low-toxicity anti-tumor drugs. Meanwhile, the pyrazole compound is wide in material sources, simple in synthesizing processes and applicable to industrial production.
Ionic liquid brush as an efficient and reusable heterogeneous catalytic assembly for the tosylation of phenols and alcohols in neat water
Feng, Simin,Li, Jing,Wei, Junfa
supporting information, p. 4743 - 4746 (2017/07/12)
A very efficient and reusable heterogeneous ionic liquid brush assembly was developed. The catalyst exhibits high catalytic activity for the tosylation of phenols and alcohols in neat water. Moreover, the catalyst shows outstanding stability and reusability, and it can be simply and effectively recovered and reused five times without noticeable loss of catalytic activity.
