1620083-08-0

Upstream product

• 956485-08-8 ((3aR,5R,6S,6aR)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyl-6-(naphthalen-2-ylmethoxy)tetrahydrofuro[2,3-d][1,3]dioxol-5-yl)methanol 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 1620083-09-1 ((3aR,5S,6S,6aR)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2,2-dimethyl-6-(naphthalen-2-ylmethoxy)-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)methanol 
• 1620083-10-4 (3aR,5S,6S,6aR)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2,2-dimethyl-6-(naphthalen-2-ylmethoxy)-dihydro-5H-furo[3,2-d][1,3]dioxole-5-carbaldehyde 
• 1620083-11-5 diethyl (E)-2-((3aR,5S,6S,6aR)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-2,2-dimethyl-6-(naphthalen-1-ylmethoxy)-dihydro-5H-furo[3,2-d][1,3]dioxol-5-yl)vinylphosphonate 

Relevant academic research and scientific papers

Syntheses of 4′-spirocyclic phosphono-nucleosides as potential inhibitors of hepatitis C virus NS5B polymerase

To discover novel nucleosides as potential antiviral agents, 4′-spirocyclic phosphono-nucleosides were designed to mimic the monophosphate of R-1479, a known nucleoside inhibitor of HCV NS5B. Bypassing the first kinase step to nucleoside monophosphate is viewed as advantageous since this phosphorylation is often observed as the rate-limiting transformation to the active NTP for many nucleosides. Efficient synthetic routes were developed with a triphenylphosphine-iodine cyclization reaction as the key step to form the tetrahydrofuran 4′-spirocycle. The desired 4′-spirocyclic phosphono-cytidine analogs 12a, 12b, and 16 were prepared in 11 steps.