1620139-66-3

Basic information

• Product Name: 4β-(((1-(2-fluorobenzyl)indol-5-yl)methyl)amino)-4-desoxypodophyllotoxin
• CAS NO: 1620139-66-3
• Molecular Weight: 650.704
• Mol File: 1620139-66-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4β-(((1-(2-fluorobenzyl)indol-5-yl)methyl)amino)-4-desoxypodophyllotoxin(CAS DataBase Reference)
• NIST Chemistry Reference: 4β-(((1-(2-fluorobenzyl)indol-5-yl)methyl)amino)-4-desoxypodophyllotoxin(1620139-66-3)
• EPA Substance Registry System: 4β-(((1-(2-fluorobenzyl)indol-5-yl)methyl)amino)-4-desoxypodophyllotoxin(1620139-66-3)

Safety Data

• Hazardous Substances Data: 1620139-66-3(Hazardous Substances Data)

Upstream product

• 345-35-7 2-fluorobenzyl chloride 
• 1196-69-6 1H-indole-5-carboxaldehyde 
• 944893-62-3 C₁₆H₁₂FNO 
• 155252-35-0 4β-amino-4-deoxypodophyllotoxin 

Relevant articles and documents

Synthesis of podophyllotoxin derivatives as potential antitumor agents

A series of novel podophyllotoxin derivatives was synthesized by coupling 4β-amino-4′-demethyl-4-desoxypodophyllotoxin (3a) or 4β-amino-4-desoxypodophyllotoxin (3b) with N-substituted 5-formylindole (2a-h). Their structures were identied by spectroscopic techniques. These novel derivatives were evaluated for cytotoxicity in vitro against HepG2 and HeLa cell lines. Compared with etoposide, most of the compounds showed more potent cytotoxicities against two tumor cell lines. Judging from the IC50 values, compound 5n is a promising agent, which is about 15 and 5 times more toxic than etoposide against HepG2 and HeLa cell lines, respectively.