1620172-46-4Relevant academic research and scientific papers
Visible-Light Promoted Distereodivergent Intramolecular Oxyamidation of Alkenes
Ren, Xiang,Guo, Qihang,Chen, Jianhui,Xie, Hujun,Xu, Qing,Lu, Zhan
, p. 18695 - 18699 (2016/12/26)
The visible-light-promoted diastereodivergent intramolecular oxyamination of alkenes is described to construct oxazolindinones, pyrrolidinones and imidazolidones via mild generation of primary amidyl radicals from functionalized hydroxylamines. A unique phenomenon of highly diastereoselective ring-opening of aziridines controlled by electron sacrifices was observed. Highly diastereoselective amino alcohols derivatives were obtained efficiently through this protocol in gram scales. The mechanistic studies suggested the isolatable anti-aziridine intermediates were generated quickly from primary amidyl radicals and the diastereoselectivities were controlled by pKavalues of the electron sacrifices.
A very mild and selective method for O-benzoylation of hydroxamic acids
Zheng, Yongsheng,Liu, Muqiong,Yuan, Yu
supporting information, p. 4404 - 4406 (2014/07/22)
Selective O-benzoylation of hydroxamic acids is achieved by the treatment of BPO and DABCO. Aliphatic alcohols are not reactive under these conditions. Various radical or oxidation sensitive functional groups are compatible with this protocol, and no anhydrous reagents or solvents are required for the high yields of the benzoylations.
