1620401-56-0

Basic information

• Product Name: (R)-6-methylamino-2-methylheptene
• Synonyms: (R)-6-methylamino-2-methylheptene
• CAS NO: 1620401-56-0
• Molecular Weight: 141.257
• Mol File: 1620401-56-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-6-methylamino-2-methylheptene(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-6-methylamino-2-methylheptene(1620401-56-0)
• EPA Substance Registry System: (R)-6-methylamino-2-methylheptene(1620401-56-0)

Safety Data

• Hazardous Substances Data: 1620401-56-0(Hazardous Substances Data)

Upstream product

• 58917-26-3 (S)-sulcatol 
• 110-93-0 6-Methyl-hept-5-en-2-on 
• 1620401-61-7 (S)-methanesulfonic acid 1,5-dimethyl-hex-4-enyl ester 
• 74-89-5 methylamine 
• 35189-96-9 3-methyl-2-butenylmagnesium chloride 

Downstream Products

• 7492-31-1 (R)-isometheptene mucate 
• 7492-31-1 (R)-isometheptene mucate 

Relevant articles and documents

IMIDAZOLINE RECEPTOR TYPE 1 LIGANDS FOR USE AS THERAPEUTICS

This disclosure provides compounds and compositions for use as analgesics and for the treatment of various conditions, such as pain, headaches, allodynia, and fibromyalgia. The disclosure also provides compounds that are ligands, and in some embodiments, modulators (e.g., agonists), for the imidazoline receptor type 1.

ISOMETHEPTENE ISOMER

The invention relates to a purified Isometheptene compound comprising the structure according to Formula (I), or a hydrochloride, or a pharmaceutically acceptable addition salt thereof. In particular, the disclosure relates to the synthesis, purification and characterization of an Isometheptene isomer mucate crystal 2, wherein the Isometheptene isomer 2 is stereochemically characterized as (R)-enantiomer, respectively. The Isometheptene (R)-enantiomer activity indicates a selective centrally acting selective ligand for Imidazoline subtype 1 (I1) receptor sites; and more specifically, the disclosure provides an antihypertensive composition for treatment of migraine and other neurovascular or neurogenic pain from abdominal distress. (R)-Isometheptene enantiomer or isomer 2 may be an anti-hypertensive agent with lower side effects than the racemate form. Therefore (R)-Isometheptene is believed to be effective against episodic tension-type headaches (ETTH). The (R)-Isometheptene enantiomer or isomer 2 is believed to effectively lower blood pressure, used alone or together with other headache ameliorating drugs. Methods of synthesis and treatment are described. Regarding (R)-Isometheptene crystals data of X-ray crystallography are presented.