162045-53-6

Basic information

• Product Name: tert-Butyl 4-(2-oxobenzo[d]oxazol-3(2H)-yl)piperidine-1-carboxylate
• Synonyms: tert-Butyl 4-(2-oxobenzo[d]oxazol-3(2H)-yl)piperidine-1-carboxylate;tert-butyl 4-(2-oxo-2,3-dihydro-1,3-benzoxazol-3-yl)piperidine-1-carboxylate;tert-Butyl 4-(2-oxobenzo[d]oxazol-3(2H)
• CAS NO: 162045-53-6
• Molecular Formula: C₁₇H₂₂N₂O₄
• Molecular Weight: 318.371
• Mol File: 162045-53-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 435.6°C at 760 mmHg
• Flash Point: 217.244°C
• Appearance: /
• Density: 1.246g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: tert-Butyl 4-(2-oxobenzo[d]oxazol-3(2H)-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 4-(2-oxobenzo[d]oxazol-3(2H)-yl)piperidine-1-carboxylate(162045-53-6)
• EPA Substance Registry System: tert-Butyl 4-(2-oxobenzo[d]oxazol-3(2H)-yl)piperidine-1-carboxylate(162045-53-6)

Safety Data

• Hazardous Substances Data: 162045-53-6(Hazardous Substances Data)

Usage

General Description

Tert-butyl 4-(2-oxobenzo[d]oxazol-3(2H)-yl)piperidine-1-carboxylate is a complex chemical compound with a molecular formula C19H23N3O4. It is a piperidine derivative containing a benzooxazole moiety. This chemical is often used in scientific research and drug development due to its potential biological activity. Its unique structure and hydrophobic properties make it a valuable tool in the study of biological systems, particularly in the field of medicinal chemistry. Additionally, this compound may have potential applications in the development of new pharmaceuticals and other bioactive compounds.

InChI:InChI=1/C17H22N2O4/c1-17(2,3)23-15(20)18-10-8-12(9-11-18)19-13-6-4-5-7-14(13)22-16(19)21/h4-7,12H,8-11H2,1-3H3

Upstream product

• 59-49-4 2-Benzoxazolinone 
• 1972-28-7 diethylazodicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 95-55-6 2-amino-phenol 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 162045-48-9 1-(tert-butoxycarbonyl)-4-[(2-hydroxyphenyl)amino]piperidine 

Downstream Products

• 173842-04-1 5-Chloro-1,1-dioxido-2-(4-(4-(2-oxo-3-benzoxazolinyl)-piperidin-1-yl)-butyl)-1,2-benzisothiazol-3(2H)-one 
• 215878-20-9 4-[2(3H)-oxobenzoxazol-3-yl]piperidine 

Relevant articles and documents

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STAT5 is a transcription factor, a member of the STAT family of signaling proteins. STAT5 is involved in many types of cancer, including chronic myelogenous leukemia (CML), in which this protein is found constitutively activated as a consequence of BCR-ABL expression. The neuroleptic drug pimozide was recently reported to act as an inhibitor of STAT5 phosphorylation and is capable of inducing apoptosis in CML cells in vitro. Our research group has synthesized simple derivatives of pimozide with cytotoxic activity and that are able to decrease the levels of phosphorylated STAT5. In this work we continued the search for novel STAT5 inhibitors, synthesizing compounds in which the benzoimidazolinone ring of pimozide is either maintained or modified, in order to obtain further structure–activity relationship information for this class of STAT5 inhibitors. Two compounds of the series showed potent cytotoxic activity against BCR-ABL-positive and pSTAT5-overexpressing K562 cells and were able to markedly decrease the levels of phosphorylated STAT5.

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