162046-62-0

Basic information

• Product Name: 2-METHOXY-3-CHLOROMETHYL PYRIDINE
• Synonyms: 2-METHOXY-3-CHLOROMETHYL PYRIDINE;3-(CHLOROMETHYL)-2-METHOXYPYRIDINE;Pyridine, 3-(chloroMethyl)-2-Methoxy-
• CAS NO: 162046-62-0
• Molecular Formula: C₇H₈ClNO
• Molecular Weight: 157.6
• Mol File: 162046-62-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: Oil°
• Boiling Point: 221.85°C at 760 mmHg
• Flash Point: 87.972°C
• Appearance: /
• Density: 1.173g/cm³
• Vapor Pressure: 0.156mmHg at 25°C
• Refractive Index: 1.519
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.62±0.10(Predicted)
• CAS DataBase Reference: 2-METHOXY-3-CHLOROMETHYL PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-3-CHLOROMETHYL PYRIDINE(162046-62-0)
• EPA Substance Registry System: 2-METHOXY-3-CHLOROMETHYL PYRIDINE(162046-62-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 162046-62-0(Hazardous Substances Data)

Usage

General Description

2-Methoxy-3-chloromethyl pyridine is a chemical compound that is a derivative of pyridine. It is composed of a pyridine ring with a chlorine atom at the 3-position and a methoxy group at the 2-position. This chemical is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals due to its reactivity and ability to undergo various chemical reactions. 2-Methoxy-3-chloromethyl pyridine is also known for its potent activity as an inhibitor against certain enzymes and is often utilized in medicinal chemistry research. In addition, this compound has been used as a reagent in the production of fluorinated derivatives and as a component in the manufacture of pesticides and other chemical products.

InChI:InChI=1/C7H8ClNO/c1-10-7-6(5-8)3-2-4-9-7/h2-4H,5H2,1H3

Upstream product

• 71255-09-9 2-methoxynicotinaldehyde 
• 16498-81-0 2-methoxynicotinic acid 
• 67367-26-4 2-methoxynicotinic acid methyl ester 
• 112197-16-7 (2-methoxy-pyridin-3-yl)-methanol 

Downstream Products

• 351410-37-2 (2-methoxypyridin-3-yl)acetonitrile 
• 351410-38-3 2-(2-methoxy-3-pyridyl)acetic acid 
• 1020104-73-7 N-(2-methoxy-pyridin-3-ylmethyl)-N-(4-p-tolyloxy-phenyl)-methane-sulfonamide 

Relevant articles and documents

MAXI-K POTASSIUM CHANNEL OPENERS FOR THE TREATMENT OF FRAGILE X ASSOCIATED DISORDERS

The present invention relates to the compounds of formula (I) and pharmaceutical compositions containing these compounds. The compounds provided herein can act as maxi-K potassium channel openers, which makes them suitable for use in therapy, particularly in the treatment or prevention of fragile X associated disorders, such as fragile X syndrome.

ISOQUINOLINES AS INHIBITORS OF HPK1

Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.

Structure-activity relationships (SAR) and structure-kinetic relationships (SKR) of sulphone-based CRTh2 antagonists

Monocyclic and bicyclic ring systems were investigated as the "core" section of a series of diphenylsulphone-containing acetic acid CRTh2 receptor antagonists. A range of potencies were observed and single-digit nanomolar potencies were obtained in both the monocyclic and bicyclic cores. Residence times for the monocyclic compounds were very short. Some of the bicyclic cores displayed better residence times. A methyl group in the northern part of the core, between the head and tail was a necessary requirement for the beginnings of long residence times. Variations of the tail substitution maximised potencies and residence times.