1620580-01-9

Upstream product

• 1620580-00-8 N-(2-bromophenyl)-4-(((2-iodophenyl)amino)methyl)-2,5-dimethoxyaniline 
• 75-36-5 acetyl chloride 
• 1620579-95-4 4-((2-bromophenyl)amino)-2,5-dimethoxybenzaldehyde 
• 90064-47-4 4-iodo-2,5-dimethoxybenzenecarbaldehyde 
• 93-02-7 2,5-dimethoxybenzaldehyde 

Relevant academic research and scientific papers

Palladium mediated intramolecular multiple C-X/C-H cross coupling and C-H activation: Synthesis of carbazole alkaloids calothrixin B and murrayaquinone A

Straightforward palladium mediated syntheses of calothrixin B and murrayaquinone A are described. Regioselective palladium mediated intramolecular multiple C-X/C-H cross coupling reaction on N-(4-((2-bromophenyl)amino)-2,5- dimethoxybenzyl)-N-(2-iodophenyl)acetamide followed by CAN oxidation afforded calothrixin B in excellent yield in two steps. A linear synthesis has also been developed for calothrixin B. Utilizing C-H functionalization as well as palladium mediated intramolecular C-X/C-H cross coupling reaction, murrayaquinone A synthesis was achieved. Overall, these synthetic methodologies provide an expedient entry to these biologically active alkaloids in a short reaction sequence. This journal is the Partner Organisations 2014.