1620580-36-0Relevant academic research and scientific papers
Rh(III)-Catalyzed meta-C-H Olefination Directed by a Nitrile Template
Xu, Hua-Jin,Lu, Yi,Farmer, Marcus E.,Wang, Huai-Wei,Zhao, Dan,Kang, Yan-Shang,Sun, Wei-Yin,Yu, Jin-Quan
supporting information, p. 2200 - 2203 (2017/02/23)
A range of Rh(III)-catalyzed ortho-C-H functionalizations have been developed; however, extension of this reactivity to remote C-H functionalizations through large-ring rhodacyclic intermediates has yet to be demonstrated. Herein we report the first examp
Pd(II)-catalyzed meta-C-H olefination, arylation, and acetoxylation of indolines using a U-shaped template
Yang, Guoqiang,Lindovska, Petra,Zhu, Dajian,Kim, Justin,Wang, Peng,Tang, Ri-Yuan,Movassaghi, Mohammad,Yu, Jin-Quan
, p. 10807 - 10813 (2014/08/18)
meta-C-H olefination, arylation, and acetoxylation of indolines have been developed using nitrile-containing templates. The combination of a monoprotected amino acid ligand and the nitrile template attached at the indolinyl nitrogen via a sulfonamide linkage is crucial for the meta-selective C-H functionalization of electron-rich indolines that are otherwise highly reactive toward electrophilic palladation at the para-positions. A wide range of synthetically important and advanced indoline analogues are selectively functionalized at the meta-positions.
