16206-34-1

Upstream product

• 100-47-0 benzonitrile 
• 93-91-4 1-phenylbutan-1,3-dione 
• 103896-55-5 N-(1-Phenylvinylimino)triphenylphosphorane 
• 2114-00-3 2-bromo-1-phenyl-1-propanone 
• 30085-70-2 [E]-1-morpholino-1-phenyl-1-propene 
• 15982-59-9 2-methyl-1,4-diphenylbutane-1,4-dione 
• 16717-64-9 1-azidostyrene 
• 4767-01-5 2-methyl-3-oxo-3-phenylpropionic acid 
• 1428931-89-8 (E)-1-phenyl-N-(1-phenylethylidene)prop-2-en-1-amine 
• 4393-21-9 1-(phenyl)allylamine 
• 98-86-2 acetophenone 
• 93-56-1 phenylethane 1,2-diol 
• 93-55-0 1-phenyl-propan-1-one 
• 23517-42-2 propiophenone oxime 

Relevant academic research and scientific papers

A robust NNP-type ruthenium (II) complex for alcohols dehydrogenation to esters and pyrroles

A Ru (II) complex bearing pyridyl-based benzimidazole-phosphine tridentate NNP ligand was synthesized and structurally characterized by NMR, IR. The complex can efficiently and selectively catalyze the acceptorless dehydrogenation of primary alcohols to esters under relatively mild conditions and the synthesis of pyrroles by means of the reactions of secondary alcohols and β-amino alcohols through acceptorless deoxygenation condensation.

A Versatile Ru(II)-NNP Complex Catalyst for the Synthesis of Multisubstituted Pyrroles and Pyridines

A pincer-type Ru(II)-NNP complex bearing a pyrazolyl-(NH-PtBu2)-pyridine ligand was synthesized and structurally characterized by NMR, IR, elemental analysis, and X-ray single-crystal crystallographic determinations, which efficiently catalyzed the synthesis of multisubstituted pyrroles and pyridines by means of the reactions of secondary alcohols and β- or γ-amino alcohols through deoxygenation and selective C-N and C-C bond formation. The coupling reactions took place with 0.3 mol % catalyst loading and tolerated diverse functional groups. The present work provides an alternative method to construct highly active transition-metal complex catalysts from readily available ligands.

Divergent Iron-Catalyzed Coupling of O-Acyloximes with Silyl Enol Ethers

An iron-catalyzed coupling reaction of O-acyloximes and O-benzoyl amidoximes with silyl enol ethers is reported. The protocol provides access to functionalized pyrroles, 1,6-ketonitriles, pyrrolines and imidazolines via carbon-centered radicals generated from an initially formed iminyl radical. The intramolecular cyclization and ring-opening processes of the iminyl radical take place preferentially over reactions that proceed through a 1,3-hydrogen transfer, providing insights into iron-catalyzed reactions with oxime derivatives. The cheap and environmentally friendly iron catalyst, the broad substrate scope and the functional group compatibility make this protocol useful for synthesis of valuable nitrogen-containing products.

The method of manufacturing the same

PROBLEM TO BE SOLVED: To provide a method for producing a dimer which can obtain the dimer even in the absence of a specific transition metal such as Ir. SOLUTION: The method for producing a dimer comprises dimerizing an alcohol (1) (wherein R1and R2are each hydrogen or a monovalent hydrocarbon group) and an alcohol (2) (wherein R3and R4are each hydrogen or a monovalent hydrocarbon group) or a carbonyl compound (3) (wherein R3and R4are the same as defined above) in the presence of an alkali metal or an alkali metal base and in the absence of a transition metal. COPYRIGHT: (C)2011,JPOandINPIT

Method of manufacturing pyrrolecarboxylic

PROBLEM TO BE SOLVED: To provide a method obtainable of a pyrrole in a good yield. SOLUTION: As shown by chemical reaction formula (1) and chemical reaction formula (2), a β-amino alcohol is reacted with a carbonyl compound or an alcohol in the pres

α-Palladation of imines as entry to dehydrogenative heck reaction: Aerobic oxidative cyclization of N-allylimines to pyrroles

We report here a palladium(II)-catalyzed oxidative cyclization reaction of N-allylimines derived from methyl ketones, typically acetophenones, affording pyrrole derivatives at room temperature under oxygen atmosphere. The reaction likely proceeds through α-palladation of the imine followed by olefin migratory insertion and β-hydride elimination, thus representing a new example of aerobic dehydrogenative Heck cyclization.

General and regioselective synthesis of pyrroles via ruthenium-catalyzed multicomponent reactions

A general and highly regioselective synthesis of pyrroles via ruthenium-catalyzed three-component reactions has been developed. A variety of ketones including less reactive aryl and alkyl substrates were efficiently converted in combination with different

Aerobic synthesis of pyrroles and dihydropyrroles from imines: Palladium(II)-catalyzed intramolecular C-H dehydrogenative cyclization

sp3ectacularly mild! An efficient PdII-catalyzed intramolecular dehydrogenative cyclization of imines affords (dihydro)pyrrole products using molecular oxygen as the sole oxidant. This mild formal sp 3-C-H functionalization allows rapid and atom-economical assembly of (dihydro)pyrrole rings from inexpensive and readily available allylamines and ketones. A broad range of functional groups are tolerated. Copyright

Manganese(III)-catalyzed formal [3+2] annulation of vinyl azides and ?-keto acids for synthesis of pyrroles

Manganese(III)-catalyzed formal [3+2] annnulation of vinyl azides and -keto acids has been developed for the synthesis of substituted NH pyrroles with a wide range of substituents. Georg Thieme Verlag Stuttgart.

Cyclocondensation of α-aminonitriles and enones: A short access to 3,4-dihydro-2H-pyrrole 2-carbonitriles and 2,3,5-trisubstituted pyrroles

(Chemical Equation Presented) The reaction of α,β-unsaturated carbonyl compounds with aminoacetonitrile hydrochloride furnishes 3,5-disubstituted 3,4-dihydro-2H-pyrrole-2-carbonitriles in a one-pot reaction sequence. While these products can serve as starting materials for the preparation of polysubstituted pyrrolizidines, they are kinetically stable against the base-induced elimination of HCN. In contrast, their 2-substituted analogues obtained from α-substituted α-aminonitriles can be readily converted to the corresponding 2,3,5-trisubstituted pyrroles under microwave irradiation. The key step presumably involves the thermal electrocyclization of a stabilized 2-azapentadienyl anion formed by condensation of the reactants and subsequent deprotonation.